Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Dokholyan, N. V."'
Autor:
Urbanc, B., Cruz, L., Ding, F., Sammond, D., Khare, S., Buldyrev, S. V., Stanley, H. E., Dokholyan, N. V.
Recent experiments with amyloid-beta (Abeta) peptide suggest that formation of toxic oligomers may be an important contribution to the onset of Alzheimer's disease. The toxicity of Abeta oligomers depends on their structure, which is governed by asse
Externí odkaz:
http://arxiv.org/abs/physics/0403040
We study the aggregation of peptides using the discrete molecular dynamics simulations. At temperatures above the alpha-helix melting temperature of a single peptide, the model peptides aggregate into a multi-layer parallel beta-sheet structure. This
Externí odkaz:
http://arxiv.org/abs/cond-mat/0312702
Experimental observations suggest that proteins follow different pathways under different environmental conditions. We perform molecular dynamics simulations of a model of the SH3 domain over a broad range of temperatures, and identify distinct pathw
Externí odkaz:
http://arxiv.org/abs/physics/0305087
Universality in the behavior of complex systems often reveals itself in the form of scale-invariant distributions that are essentially independent of the details of the microscopic dynamics. A representative paradigm of complex behavior in nature is
Externí odkaz:
http://arxiv.org/abs/cond-mat/0005178
Akademický článek
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Akademický článek
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Autor:
Kursun, O., Homan, P. J., Weeks, K. M., Favorov, O. V., Busan, S., Ge, X., Lavender, C. A., Dokholyan, N. V.
RNA molecules function as the central conduit of information transfer in biology. To do this, they encode information both in their sequences and in their higher-order structures. Understanding the higher-order structure of RNA remains challenging. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb52e96e102f87045a83357d88083193
Autor:
Randell, S. H., Cholon, D. M., Quinney, N. L., Boucher, R. C., Esther, C. R., Das, J., Dokholyan, N. V., Fulcher, M. L., Gentzsch, M.
Cystic Fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR). Newly developed “correctors” such as lumacaftor (VX-809) that improve CFTR maturation and trafficking and “potentiators” such as ivacaftor (VX-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1699509952a89339f73364134fc5760d
Publikováno v:
Proteins. 82(4)
The equilibrium properties of a HIV-1-protease precursor are studied by means of an efficient molecular dynamics scheme, which allows for the simulation of the folding of the protein monomers and their dimerization into an active form and compare the
Autor:
Shirvanyants, D., Freisinger, C. M., Huttenlocher, A., Ding, F., Dagliyan, O., Dokholyan, N. V., Fee, L., Karginov, A. V., Smolen, G. A., Hahn, K. M., Chandrasekaran, S. N.
Design of a regulatable multistate protein is a challenge for protein engineering. Here we design a protein with a unique topology, called uniRapR, whose conformation is controlled by the binding of a small molecule. We confirm switching and control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74ca3c3f96f7e5f1c0209faad2db08e2