Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD+ depletion [version 1; peer review: 2 approved]

Autor: Oakey, LA, Fletcher, RS, Elhassan, YS, Cartwright, DM, Doig, CL, Garten, A, Thakker, A, Maddocks, ODK, Zhang, T, Tennant, DA, Ludwig, C, Lavery, GG

Background: Skeletal muscle is central to whole body metabolic homeostasis, with age and disease impairing its ability to function appropriately to maintain health. Inadequate NAD+ availability is proposed to contribute to pathophysiology by impairin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::12a84c8f50e087e69ef65ab7f85d863d
https://irep.ntu.ac.uk/id/eprint/38193/1/1215195_Doig.pdf

Glucocorticoids re-programme the beta cell signalling cassette to preserve functional identity and insulin secretion

Autor: Fine, NHF, Doig, CL, Elhassan, Y, Marchetti, P, Bugliani, M, Piemonti, L, Rutter, GA, Jacobson, DA, Lavery, GG, Hodson, DJ

Publikováno v: 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)
S83

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::7371e71ade9196c93ad8a766ff01ecb8
http://hdl.handle.net/10044/1/52822

11β-HSD1 modulates the set point of brown adipose tissue response to glucocorticoids in male mice

Autor: Doig, CL, Fletcher, RS, Morgan, SA, McCabe, EL, Larner, DP, Tomlinson, JW, Stewart, PM, Philp, A, Lavery, GG

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::37071008e10de7fafb2a938a7a74c190
https://ora.ox.ac.uk/objects/uuid:070d53df-a219-4ea5-9cd1-b8c363d4f383

Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism

Autor: Morgan, SA, Hassan-Smith, ZK, Doig, CL, Sherlock, M, Stewart, PM, Lavery, GG

The adverse metabolic effects of prescribed and endogenous glucocorticoid excess, ‘Cushing’s syndrome’, create a significant health burden. While skeletal muscle atrophy and resultant myopathy is a clinical feature, the molecular mechanisms und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::be6adeeaa1c32d272c29b64e7290f2d2

Contribution of local regeneration of glucocorticoids to tissue steroid pools.

Autor: Khan S; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Livingstone DEW; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Centre for Discovery Brain Science, University of Edinburgh, Hugh Robson Building, Edinburgh, UK., Zielinska A; College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Doig CL; Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK., Cobice DF; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Esteves CL; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Man JTY; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Homer NZM; Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Seckl JR; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., MacKay CL; SIRCAMS, School of Chemistry, University of Edinburgh, Joseph Black Building, King's Buildings, Edinburgh, UK., Webster SP; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Lavery GG; Department of Biosciences, School of Science & Technology, Nottingham Trent University, Nottingham, UK., Chapman KE; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Walker BR; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Clinical & Translational Research Institute, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK., Andrew R; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Mass Spectrometry Core Laboratory, Edinburgh Clinical Research Facility, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

Publikováno v: The Journal of endocrinology [J Endocrinol] 2023 Jul 28; Vol. 258 (3). Date of Electronic Publication: 2023 Jul 28 (Print Publication: 2023).