Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.

Autor: Otten AB; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Stassen AP; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Adriaens M; Maastricht Centre for Systems Biology, Maastricht University, 6200 MD, The Netherlands., Gerards M; Maastricht Centre for Systems Biology, Maastricht University, 6200 MD, The Netherlands., Dohmen RG; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Timmer AJ; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Vanherle SJ; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Kamps R; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Boesten IB; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Vanoevelen JM; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands., Muller M; Laboratory of Organogenesis and Regeneration, Interdisciplinary Cluster for Applied Genoproteomics Research, Univérsité de Liège, 4000, Belgium., Smeets HJ; Department of Genetics and Cell Biology, Clinical Genomics Unit, School for Oncology and Developmental Biology, Maastricht University, 6200 MD, The Netherlands bert.smeets@maastrichtuniversity.nl.; Maastricht Centre for Systems Biology, Maastricht University, 6200 MD, The Netherlands.

Publikováno v: Genetics [Genetics] 2016 Dec; Vol. 204 (4), pp. 1423-1431. Date of Electronic Publication: 2016 Oct 21.