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Decreased cellular excitability of pyramidal tract neurons in primary motor cortex leads to paradoxically increased network activity in simulated parkinsonian motor cortex.

Autor: Doherty DW; Department of Physiology & Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Chen L; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington D.C., USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Smith Y; Emory National Primate Research Center, Department of Neurology, Udall Center of Excellence for Parkinson's Disease Research, Emory University, School of Medicine, Atlanta GA 30329 USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Wichmann T; Emory National Primate Research Center, Department of Neurology, Udall Center of Excellence for Parkinson's Disease Research, Emory University, School of Medicine, Atlanta GA 30329 USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Chu HY; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington D.C., USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815., Lytton WW; Department of Physiology & Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.; Kings County Hospital, Brooklyn, NY 11203, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 23. Date of Electronic Publication: 2024 Jun 23.