MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer.

Autor: Doha ZO; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.; Department of medical laboratory technology, Taibah University, Al-Madinah al-Munawwarah, Saudi Arabia., Wang X; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Calistri NL; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA., Eng J; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA., Daniel CJ; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Ternes L; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA., Kim EN; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA., Pelz C; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA., Munks M; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA., Betts C; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Kwon S; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA., Bucher E; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA., Li X; Division of Oncologic Sciences, Oregon Health and Science University, Portland, OR, USA., Waugh T; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Tatarova Z; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA., Blumberg D; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA., Ko A; Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA., Kirchberger N; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Pietenpol JA; Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Sanders ME; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Langer EM; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Dai MS; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Mills G; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Division of Oncologic Sciences, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Chin K; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Chang YH; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Coussens LM; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Gray JW; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Heiser LM; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.; OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Sears RC; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA. searsr@ohsu.edu.; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, OR, USA. searsr@ohsu.edu.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. searsr@ohsu.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Sep 13; Vol. 14 (1), pp. 5665. Date of Electronic Publication: 2023 Sep 13.