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Public Regulatory Databases as a Source of Insight for Neuromodulation Devices Stimulation Parameters

Autor: Shawn C. Kelley, Victor Krauthamer, Gregory F. Molnar, Benjamin P. Hahn, Alan Shi, Dawn Bardot, Darrel F. Untereker, Eric M Hudak, Hyowon Lee, Chris Condit, G. Karl Steinke, Jose A. Centeno, Doe Kumsa, Pavel Takmakov, Fred W. Montague

Publikováno v: Neuromodulation: Technology at the Neural Interface. 21:117-125

Objective The Shannon model is often used to define an expected boundary between non-damaging and damaging modes of electrical neurostimulation. Numerous preclinical studies have been performed by manufacturers of neuromodulation devices using differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048270743a9709335069e4276cebc62d
https://doi.org/10.1111/ner.12641

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The electrocatalytic properties of adsorbed hemin and its nitrosyl adduct on glassy carbon surfaces toward hydroxylamine in aqueous neutral electrolytes

Autor: Doe Kumsa, Adriel Jebin Jacob Jebaraj, B. Kannan, Daniel Alberto Scherson, Nicholas S. Georgescu, Alia Méndez-Albores

Publikováno v: Journal of Electroanalytical Chemistry. 793:250-256

Cyclic voltammetry and dynamic and steady state polarization measurements have been used to examine the electrocatalytic activity of glassy carbon, GC, bearing a layer of adsorbed hemin, Hm, Hm | GC, toward hydroxylamine, NH 2 OH, in neutral aqueous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b862de73b614efe8f4537d8ccf821494
https://doi.org/10.1016/j.jelechem.2017.02.017

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High-throughput in vitro assay to evaluate the cytotoxicity of liberated platinum compounds for stimulating neural electrodes

Autor: Doe Kumsa, Darrel F. Untereker, Jeffrey R. Capadona, Horst A. von Recum, Vishnupriya Srivastava, Kyle M. Kovach, Eric M Hudak, Shawn C. Kelley

Publikováno v: Journal of Neuroscience Methods. 273:1-9

Background It is currently unclear how the platinum (Pt) species released from platinum-containing stimulating electrodes may affect the health of the surrounding tissue. This study develops an effective system to assess the cytotoxicity of any elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035d6a5d1e34c84d768b94f4dd4d2168
https://doi.org/10.1016/j.jneumeth.2016.07.018

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Electron transfer processes occurring on platinum neural stimulating electrodes: pulsing experiments for cathodic-first, charge-balanced, biphasic pulses for 0.566 ⩽ k ⩽ 2.3 in rat subcutaneous tissues

Autor: Eric M Hudak, Doe Kumsa, Narendra Bhadra, J. Thomas Mortimer

Publikováno v: Journal of neural engineering. 14(5)

OBJECTIVE Charge injection through platinum neural stimulation electrodes is often constrained by the Shannon limit (Shannon 1992 IEEE Trans. Biomed. Eng. 39 424-6) of k = 1.75. By leveraging the tools of electrochemistry to better understand the rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e02223d0b9b3ac8299f53eaa80bff5
https://pubmed.ncbi.nlm.nih.gov/28813367

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Electron transfer processes occurring on platinum neural stimulating electrodes: a tutorial on the i(V e) profile

Autor: J. Thomas Mortimer, Darrel F. Untereker, Shawn C. Kelley, Doe Kumsa, Eric M Hudak, Narendra Bhadra

Publikováno v: Journal of neural engineering. 13(5)

The aim of this tutorial is to encourage members of the neuroprosthesis community to incorporate electron transfer processes into their thinking and provide them with the tools to do so when they design and work with neurostimulating devices. The foc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e779f5df3efedda21f798dbd0ef5c1b
https://pubmed.ncbi.nlm.nih.gov/27518125

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Electron transfer processes occurring on platinum neural stimulating electrodes: pulsing experiments for cathodic-first/charge-balanced/biphasic pulses for 0.566 ≤ k ≤ 2.3 in oxygenated and deoxygenated sulfuric acid

Autor: J. Thomas Mortimer, Eric M Hudak, Fred W. Montague, Doe Kumsa

Publikováno v: Journal of neural engineering. 13(5)

The application of a train of cathodic-first/charge-balanced/biphasic pulses applied to a platinum electrode resulted in a positive creep of the anodic phase potential that increases with increasing charge injection but reaches a steady-state value b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d5ba51013812a114cead538a079055
https://pubmed.ncbi.nlm.nih.gov/27464506

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Real time imaging of peripheral nerve vasculature using optical coherence angiography

Autor: Cristin G. Welle, Doe Kumsa, Daniel X. Hammer, Pavel Takmakov, Srikanth Vasudevan

Publikováno v: Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation.

The peripheral nervous system (PNS) carries bidirectional information between the central nervous system and distal organs. PNS stimulation has been widely used in medical devices for therapeutic indications, such as bladder control and seizure cessa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a3fba20fa0d17d23b434e4f49d013b
https://doi.org/10.1117/12.2213160

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Oxidation of Hydroxylamine on Gold Electrodes in Aqueous Electrolytes: Rotating Ring-Disk and In Situ Infrared Reflection Absorption Spectroscopy Studies

Autor: Daniel Alberto Scherson, Doe Kumsa, Adriel Jebin Jacob Jebaraj

Publikováno v: The Journal of Physical Chemistry C. 116:6932-6942

The oxidation of hydroxylamine on Au electrodes in aqueous phosphate buffer solutions (pH 7) was examined using electrochemical and in situ infrared reflection absorption spectroscopy techniques. Polarization curves recorded with a rotating Au disk e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9533f0289d9e6373833993788f57053
https://doi.org/10.1021/jp2104566

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