Dynamic equilibrium of the Aurora-A kinase activation loop revealed by single molecule spectroscopy

Autor: Gilburt, JAH, Sarkar, H, Sheldrake, P, Blagg, J, Ying, L, Dodson, CA

The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic activity and influences the binding of small-molecule inhibitors. By using single-molecule fluorescence spectroscopy, we have determined that phosphorylated Auror

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::0d3d9356b023a239855ef7dbe6f9da60
http://hdl.handle.net/10044/1/49334

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