Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dodo Chikvashvili"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13556 (2021)
The polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin1A (Syx), was previously shown by us to act as a fusion clamp in PC12 cells, as charge neutralization of 5RK promotes spontaneous and inhibits Ca2+-triggered rele
Externí odkaz:
https://doaj.org/article/f9ef4efe05ad413f8b95cd3168e10651
Autor:
Noa Regev, Nurit Degani-Katzav, Alon Korngreen, Adi Etzioni, Sivan Siloni, Alessandro Alaimo, Dodo Chikvashvili, Alvaro Villarroel, Bernard Attali, Ilana Lotan
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6586 (2009)
KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern within neurons, with uniqu
Externí odkaz:
https://doaj.org/article/8a52ffdfa7b84c1d8195262192e537be
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1381 (2008)
K(+) efflux through voltage-gated K(+) (Kv) channels can attenuate the release of neurotransmitters, neuropeptides and hormones by hyperpolarizing the membrane potential and attenuating Ca(2+) influx. Notably, direct interaction between Kv2.1 channel
Externí odkaz:
https://doaj.org/article/47a71351f69a468982581c3dda5b17da
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13556, p 13556 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13556
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13556
The polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin1A (Syx), was shown by us to act as a fusion clamp in PC12 cells, making release dependent on stimulation by Ca2+. By using a Syx-based FRET probe, we demonstrate
Autor:
Rachel Nachman, Jens Rettig, Uri Ashery, Ilana Lotan, Dodo Chikvashvili, Reut Friedrich, Lori Feinshreiber, Anton Sheinin, Ofer Yizhar, Dafna Singer-Lahat, Ulf Matti
Publikováno v:
Journal of Cell Science. 123:1940-1947
Regulation of exocytosis by voltage-gated K+ channels has classically been viewed as inhibition mediated by K+ fluxes. We recently identified a new role for Kv2.1 in facilitating vesicle release from neuroendocrine cells, which is independent of K+ f
Publikováno v:
Biochemistry. 47:8342-8349
Previously, we have demonstrated physical and functional interactions of the voltage-gated potassium channel Kv2.1 with the plasma membrane protein components of the exocytotic SNARE complex, syntaxin 1A, and the t-SNARE, syntaxin 1A/SNAP-25, complex
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 456:1121-1136
Recently, we demonstrated that the Kv2.1 channel plays a role in regulated exocytosis of dense-core vesicles (DCVs) through direct interaction of its C terminus with syntaxin 1A, a plasma membrane soluble NSF attachment receptor (SNARE) component. We
Autor:
Sivan, Siloni, Dafna, Singer-Lahat, Moad, Esa, Vlad, Tsemakhovich, Dodo, Chikvashvili, Ilana, Lotan
Publikováno v:
Journal of cell science. 128(18)
Neuronal M-type K(+) channels are heteromers of KCNQ2 and KCNQ3 subunits, and are found in cell bodies, dendrites and the axon initial segment, regulating the firing properties of neurons. By contrast, presynaptic KCNQ2 homomeric channels directly re
Autor:
Dodo Chikvashvili, Dimitrios P. Kontoyiannis, Nir Osherov, Yona Shadkchan, Gabriel Mircus, Dafna Ben-Yaakov, Nathaniel D. Albert
Publikováno v:
Antimicrobial agents and chemotherapy. 59(9)
Invasive mycotic infections have become more common during recent decades, posing an increasing threat to public health. However, despite the growing needs, treatments for invasive fungal infections remain unsatisfactory and are limited to a small nu
Autor:
Moad Esa, Vlad Tsemakhovich, Ilana Lotan, Dodo Chikvashvili, Dafna Singer-Lahat, Sivan Siloni
Publikováno v:
Journal of Cell Science.
Neuronal M-type K(+) channels are heteromers of KCNQ2 and KCNQ3 subunits, and are found in cell bodies, dendrites and the axon initial segment, regulating the firing properties of neurons. By contrast, presynaptic KCNQ2 homomeric channels directly re