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Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.

Autor: Liu C; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Lin J; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Hynes J; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Wu H; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Wrobleski ST; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Lin S; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Dhar TG; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Vrudhula VM; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Sun JH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Chao S; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Zhao R; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Wang B; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Chen BC; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Everlof G; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Gesenberg C; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Zhang H; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Marathe PH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., McIntyre KW; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Taylor TL; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Gillooly K; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Shuster DJ; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., McKinnon M; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Dodd JH; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Barrish JC; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Schieven GL; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States., Leftheris K; Research and Development, Bristol-Myers Squibb , Princeton, New Jersey 08543, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Oct 08; Vol. 58 (19), pp. 7775-84. Date of Electronic Publication: 2015 Sep 22.

Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.

Autor: Sheppeck JE 2nd; Ironwood Pharmaceuticals, Cambridge, MA 02142, United States. jim.sheppeck@bms.com, Gilmore JL, Xiao HY, Dhar TG, Nirschl D, Doweyko AM, Sack JS, Corbett MJ, Malley MF, Gougoutas JZ, Mckay L, Cunningham MD, Habte SF, Dodd JH, Nadler SG, Somerville JE, Barrish JC

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Oct 01; Vol. 23 (19), pp. 5442-7. Date of Electronic Publication: 2013 Jul 09.