Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dodam Moon"'
Autor:
Dodam Moon, Hyomin Park, Injoo Hwang, Areum Cha, Hyunji Yun, Jaewon Lee, Sung‐Hye Park, Eun Ju Lee, Hyo‐Soo Kim
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/41d23966bbd3435b9907bd40366d84f0
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Background The homing capacity of human mesenchymal stem cells (hMSCs) to the injured sites enables systemic administration of hMSCs in clinical practice. In reality, only a small proportion of MSCs are detected in the target tissue, which i
Externí odkaz:
https://doaj.org/article/0b02c568eebc447993e826786806f701
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fi
Externí odkaz:
https://doaj.org/article/59d8906d9c154991bd3f5290be2a46ec
Autor:
Eun Ju Lee, Injoo Hwang, Gi-Hwan Kim, Dodam Moon, Su Yeon Kang, In-Chang Hwang, Seo-Yeon Lee, P.J. Marie, Hyo-Soo Kim
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 503-511 (2019)
In our previous study, we identified differences in the levels of CDH2 and vascular endothelial growth factor (VEGF) between effective and ineffective clones of human umbilical cord blood (hUCB) mesenchymal stem cells (MSCs), with regard to the infar
Externí odkaz:
https://doaj.org/article/3812fba1fefb41298120b64258c1038b
The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3,000 chemicals using cell array system where human HSCs line LX2 cells are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd53cc2b1c1b30676f2129b3bc00cfc
https://doi.org/10.21203/rs.3.rs-2232319/v1
https://doi.org/10.21203/rs.3.rs-2232319/v1
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-15 (2021)
Cell & Bioscience
Cell & Bioscience
Background The homing capacity of human mesenchymal stem cells (hMSCs) to the injured sites enables systemic administration of hMSCs in clinical practice. In reality, only a small proportion of MSCs are detected in the target tissue, which is a major
Additional file 1: Figure S1. A. Immunofluorescent detection of HMGB1 (green) and nucleus (DAPI, blue) in the liver tissue of normal and Lrat:Cas9-ERT2: sgTif1γ mice treated with TMX. The DIC image shows the phenotype of the cells. Scale bar: 50 μm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5dc9e7ec7981f82d6fbb23f15aa131
Publikováno v:
Cell & Bioscience
Cell & Bioscience, Vol 11, Iss 1, Pp 1-19 (2021)
Cell & Bioscience, Vol 11, Iss 1, Pp 1-19 (2021)
Background Hepatic stellate cells (HSCs) are activated in response to liver injury with TIF1γ-suppression, leading to liver fibrosis. Here, we examined the mechanism how reduction of TIF1γ in HSCs induces damage on hepatocytes and liver fibrosis. M
Autor:
Seo Yeon Lee, Sung Hye Park, Hyomin Park, Ji Yeon Lee, Eun Ju Lee, Dae Won Jun, Jong Nam Park, Keun Cheon Kim, Injoo Hwang, Irene Kim, Hyo-Soo Kim, Dodam Moon, Hong Sug Kim
Publikováno v:
The Journal of Experimental Medicine
This study demonstrates that loss of TIF1γ in HSC aggravates fibrosis and that TIF1γ, identified as a novel target, has potential in the development of new therapeutic approaches to inhibiting or treating liver fibrosis.
Transforming growth fa
Transforming growth fa
Autor:
Hwan-Woo Park, Jong Nam Park, Hyomin Park, Jaewon Lee, Areum Cha, Dodam Moon, Hyo-Soo Kim, Hyunji Yun, Mi-Sook Chang, Injoo Hwang, Eun Ju Lee, Keun Cheon Kim
Publikováno v:
Biomaterials. 275:120980
We expanded the application of endothelin-1 (EDN1) by treating human mesenchymal stem cell (hMSC) organotypic spinal cord slice cultures with EDN1. EDN1-treated hMSCs significantly enhanced neuronal outgrowth. The underlying mechanism of this effect