Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Docking studie"'
Autor:
Marco Persico, Raffaele Sessa, Elena Cesaro, Irene Dini, Paola Costanzo, Alberto Ritieni, Caterina Fattorusso, Michela Grosso
Publikováno v:
Cell Biology and Toxicology.
Aflatoxin B1 (AFB1), produced by fungi of the genus Aspergillus, is the most toxic and carcinogenic mycotoxin among the classes of aflatoxins. Previous research showed that AFB1 affects vitamin D receptor (VDR) expression. In the present study, integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf3def4ba862f9311ef842208422f99
https://doi.org/10.1007/s10565-022-09752-y
https://doi.org/10.1007/s10565-022-09752-y
Autor:
Karol Wtorek, Alessia Ghidini, Luca Gentilucci, Anna Adamska-Bartłomiejczyk, Justyna Piekielna-Ciesielska, Chiara Ruzza, Chiara Sturaro, Girolamo Calò, Stefano Pieretti, Alicja Kluczyk, John McDonald, David G. Lambert, Anna Janecka
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12700
Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c952bd506bc065eaeb9ec43ae71ec84
https://hdl.handle.net/11585/904457
https://hdl.handle.net/11585/904457
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense
Autor:
Carla Di Chio, Santo Previti, Giorgio Amendola, Rahul Ravichandran, Annika Wagner, Sandro Cosconati, Ute A. Hellmich, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
In this paper, we developed a new series of dipeptide nitriles that were demonstrated to be reversible rhodesain inhibitors at nanomolar level, with EC50 values against cultured T. b. brucei in the micromolar range. We also proved that our dipeptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2964c5b49a8c25aaa543adb15a858e46
http://hdl.handle.net/11591/469094
http://hdl.handle.net/11591/469094
Autor:
Roberta Ettari, Maria Zappalà, Ettore Novellino, Silvana Grasso, Carmen Cerchia, Alessandra Bitto, Manuela Guccione, Santina Maiorana, Antonio Lavecchia
Publikováno v:
ChemMedChem. 14:842-852
The development of immunoproteasome-selective inhibitors is a promising strategy for treating hematologic malignancies, autoimmune and inflammatory diseases. In this context, we report the design, synthesis, and biological evaluation of a new series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec550e7b972b1a44d6d30b9fff0e464
https://doi.org/10.1002/cmdc.201900028
https://doi.org/10.1002/cmdc.201900028
Autor:
Nicole Kopp, Erik Laurini, Hans-Ulrich Humpf, Dirk Schepmann, Carmen Almansa, Francisco R. Nieto, Sabrina Pricl, Gianluca Civenni, Domenico Marson, Carlo V. Catapano, Bernhard Wünsch
1,3-Dioxanes 1 and cyclohexanes 2 bearing a phenyl ring and an aminoethyl moiety in 1,3-relationship to each other represent highly potent σ1 receptor antagonists. In order to increase the chemical stability of the acetalic 1,3-dioxanes 1 and the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1ecbc0b94c8f1e4352a2e829847b05
https://www.sciencedirect.com/science/article/pii/S0223523421002920?via=ihub
https://www.sciencedirect.com/science/article/pii/S0223523421002920?via=ihub
Autor:
Antonio Lavecchia, Anna Cioce, Silvana Pedatella, Michele Manfra, Carmen Cerchia, A. Bolognese
Publikováno v:
European journal of medicinal chemistry. 187
A series of l -lysine-conjugated pyridophenoxazinones 2–5 and 2′-5′ were designed and synthesized for developing compounds with multimodal anticancer potentialities. All compounds inhibited the proliferation of a panel of human liquid and solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d028a640efc986f07c42eee7b73b41
https://pubmed.ncbi.nlm.nih.gov/31869654
https://pubmed.ncbi.nlm.nih.gov/31869654
Autor:
Luisa Di Cerbo, Maria Camilla Baratto, Margherita Brindisi, Sarah D'Alessandro, Sandra Gemma, Ettore Novellino, Nicola Relitti, Donatella Taramelli, Stefania Lamponi, Giuseppe Campiani, Nicoletta Basilico, Simone Brogi, Giulia Chemi, Gloria Alfano, Rebecca Pogni, Stefania Butini
Publikováno v:
Bioorganic chemistry. 89
Despite recent advancements in its control, malaria is still a deadly parasitic disease killing millions of people each year. Progresses in combating the infection have been made by using the so-called artemisinin combination therapies (ACTs). Natura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17530cabdde81e0b35573da571de19be
https://pubmed.ncbi.nlm.nih.gov/31185392
https://pubmed.ncbi.nlm.nih.gov/31185392
Autor:
Alessia Leonetti, Filippo Basagni, Andrea Milelli, Manuela Cervelli, Paolo Mariottini, Fabio Polticelli, Anna Minarini, Michela Rosini, Maria Luisa Di Paolo, Rina Venerando, Enzo Agostinelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 740-752 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 740-752 (2019)
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5df6b8cde955d3669badc52f42c3d1
https://pubmed.ncbi.nlm.nih.gov/30829081
https://pubmed.ncbi.nlm.nih.gov/30829081
Autor:
Andrea Milelli, Maria Luisa Di Paolo, Elirosa Minniti, Francesca Zonta, Michela Rosini, Anna Minarini, Giorgio Cozza, Stefania Sarno, Fulvio Ursini
Publikováno v:
The FEBS journalReferences. 286(24)
The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for this reason are well-known and attractive pharmacological targets in neuropsychiatric and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345cb12cfd04a4963c050112fef35092
https://pubmed.ncbi.nlm.nih.gov/31291696
https://pubmed.ncbi.nlm.nih.gov/31291696
Autor:
Sabrina Pricl, Carmen Almansa, Stefanie Brune, Dirk Schepmann, Bernhard Wünsch, Frauke Weber, Kristina Friedland, Erik Laurini, Elisabeth Kronenberg
σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d9f7f1dda6bb019d48e31b4ddc2a89
https://hdl.handle.net/11368/2942758
https://hdl.handle.net/11368/2942758