Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Dock2"'
Autor:
Wei Zhang, Yan Yang, Liewen Lin, Jingquan He, Jingjing Dong, Bin Yan, Wanxia Cai, Yumei Chen, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background According to the Global Cancer Statistics in 2020, the incidence and mortality of colorectal cancer (CRC) rank third and second among all tumors. The disturbance of ubiquitination plays an important role in the initiation and deve
Externí odkaz:
https://doaj.org/article/5ee452488146449488351d832371aa06
Autor:
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionRac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control the adhesion molecules and cytoskeletal dynamics required for neutrophil recruitment to inflamed and infected organs
Externí odkaz:
https://doaj.org/article/da4fa4e646b845fabf5e025bcc8a73ed
Akademický článek
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Autor:
Kenji Morino, Kazufumi Kunimura, Yuki Sugiura, Yoshihiro Izumi, Keisuke Matsubara, Sayaka Akiyoshi, Rae Maeda, Kenichiro Hirotani, Daiji Sakata, Seiya Mizuno, Satoru Takahashi, Takeshi Bamba, Takehito Uruno, Yoshinori Fukui
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
During mucosal injury, intestinal immune cells play a crucial role in eliminating invading bacteria. However, as the excessive accumulation of immune cells promotes inflammation and delays tissue repair, it is essential to identify the mechanism that
Externí odkaz:
https://doaj.org/article/80bb3f39dd0a40a8a7f2e064a84db738
Autor:
Niusha Sharifinejad, Homa Sadri, Arash Kalantari, Samaneh Delavari, Amirhosein Noohi, Yasaman Aminpour, Araz Sabzevari, Gholamreza Azizi
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-8 (2021)
Abstract Background Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections. Case presentation We reported a novel case of a 27 m
Externí odkaz:
https://doaj.org/article/7c352c1215f84e3a9a4aa26e4c8ccf6a
Publikováno v:
Gut Pathogens, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Dysregulated gut microbiota is one of major pathogenic factors in the development of colitis. Dock2 acts as a guanine nucleotide exchange factor (GEF) and activates small G protein RAC1. Our previous study showed that, compared to
Externí odkaz:
https://doaj.org/article/c80cbdc444854b638531aa9e01f66ff1
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Naive B cells use the chemokine receptor CXCR5 to enter B cell follicles, where they scan CXCL13-expressing ICAM-1+ VCAM-1+ follicular dendritic cells (FDCs) for the presence of antigen. CXCL13-CXCR5-mediated motility is mainly driven by the Rac guan
Externí odkaz:
https://doaj.org/article/271c322feb1741a78daf35683af79de4
Akademický článek
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Association of a Novel DOCK2 Mutation-Related Gene Signature With Immune in Hepatocellular Carcinoma
Autor:
Yushen Huang, Wen Luo, Siyun Chen, Hongmei Su, Wuchang Zhu, Yuanyuan Wei, Yue Qiu, Yan Long, Yanxia Shi, Jinbin Wei
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality worldwide. Many studies have shown that dedicator of cytokinesis 2 (DOCK2) has a crucial role as a prognostic factor in various cancers. However, the potentiality o
Externí odkaz:
https://doaj.org/article/fa2d7ad0484f43dbb3b353a3beb271af
Akademický článek
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