Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dobson Benjamin Charles"'
Autor:
Dobson Benjamin Charles, Chris Wimsey, Lai C. Chan, Steven A. Raw, Anna Jawor-Baczynska, David R. J. Hose, Martin F. Jones, David Perkins, Alex L. Lamacraft, Angus E. McMillan, Matthew Burns, Alan Steven, Alexander K. Mullen, Phillip A. Inglesby, Ahmed Elmekawy, Michael John Pilling
Publikováno v:
Organic Process Research & Development. 25:858-870
Route design and process development of the small nitrogen heterocycle 2·HCl, a constituent of AZD5718 (1), is described. The novel synthetic sequence to 2.HCl involves a desymmetrizing alkylation ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9feb2b6e5b6f1298fca39c0a8116a165
https://doi.org/10.1021/acs.oprd.0c00533
https://doi.org/10.1021/acs.oprd.0c00533
Autor:
Michael David Golden, Mark Hoyle, Sarah-Kate Cantlie, Trevor Churchill, Hannah Ashton, Dobson Benjamin Charles, Paul A. Bethel, Cooper Katie Grace
Publikováno v:
Organic Process Research & Development. 23:1101-1104
Work to assess the thermal properties of 2-butynoic acid (a precursor to acalabrutinib) has revealed the potential for thermal runaway on heating; testing using accelerated rate calorimetry (ARC) showed exothermic onset from 135 °C, precluding short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9f2dca560fff85bccc541519707cc5
https://doi.org/10.1021/acs.oprd.9b00106
https://doi.org/10.1021/acs.oprd.9b00106
Publikováno v:
Angewandte Chemie
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Edition)
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Edition)
The functionalization of aryl and heteroaryls using α‐carbonyl sulfoxonium ylides without the help of a directing group has remained so far a neglected area, despite the advantageous safety profile of sulfoxonium ylides. Described herein are the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a1ceea7108c950ef15732cfe01b90
http://livrepository.liverpool.ac.uk/3062445/1/ACIE2019.pdf
http://livrepository.liverpool.ac.uk/3062445/1/ACIE2019.pdf
Autor:
Christopher Janot, Pierre Palamini, Christophe Aïssa, Dobson Benjamin Charles, James Campbell Muir
Publikováno v:
ORGANIC LETTERS
The lack of general access to bis-substituted sulfoxonium ylides is addressed by developing a palladium-catalyzed C-H cross-coupling of α-ester sulfoxonium ylides with (hetero)aryl iodides, bromides, and triflates. Three different catalysts have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8632d45c9ce66b05f198f91dd854c619