Zobrazeno 1 - 10
of 1 243
pro vyhledávání: '"Dobson, CM"'
Autor:
Scheidt, T, Carozza, JA, Kolbe, CC, Aprile, FA, Tkachenko, O, Bellaiche, MMJ, Meisl, G, Peter, QAE, Herling, TW, Ness, S, Castellana-Cruz, M, Benesch, JLP, Vendruscolo, M, Dobson, CM, Arosio, P, Knowles, TPJ
Molecular chaperones are key components of the cellular proteostasis network whose role includes the suppression of the formation and proliferation of pathogenic aggregates associated with neurodegenerative diseases. The molecular principles that all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1032::77ff3a64c145a5558da41bc6427d831a
http://hdl.handle.net/10044/1/92310
http://hdl.handle.net/10044/1/92310
Autor:
Perni, M, Flagmeier, P, Limbocker, R, Cascella, R, Aprile, Fa, Galvagnion, C, Heller, Gt, Meisl, G, Chen, Sw, Kumita, Jr, Challa, Pk, Kirkegaard, Jb, Cohen, Sia, Mannini, B, Barbut, D, Nollen, Eaa, Cecchi, C, Cremades, N, Knowles, Tpj, Chiti, F, Zasloff, M, Vendruscolo, M, Dobson, Cm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______310::643934268520e9e7d9e32fb2a8239319
http://hdl.handle.net/2158/1132660
http://hdl.handle.net/2158/1132660
Autor:
Łapińska, U, Saar, KL, Yates, EV, Herling, TW, Müller, T, Challa, PK, Dobson, CM, Knowles, T
The isoelectric point (pI) of a protein is a key characteristic that influences its overall electrostatic behaviour. The majority of conventional methods for the determination of the isoelectric point of a molecule rely on the use of spatial gradient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36b5a859b198d1f94542b9587b34115
https://www.repository.cam.ac.uk/handle/1810/265153
https://www.repository.cam.ac.uk/handle/1810/265153
Autor:
Ahn, M, Hagan, CL, Bernardo-Gancedo, A, De Genst, E, Newby, FN, Christodoulou, J, Dhulesia, A, Dumoulin, M, Robinson, CV, Dobson, CM, Kumita, JR
The conversion of human lysozyme into amyloid fibrils is associated with a rare but fatal hereditary form of nonneuropathic systemic amyloidosis. The accumulation of large amounts of aggregated protein is thought to be initiated by the formation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc50596ba9dc6bb8ff5e360a3bbc5978
https://eprints.bbk.ac.uk/id/eprint/18499/1/18499.pdf
https://eprints.bbk.ac.uk/id/eprint/18499/1/18499.pdf
Autor:
Bongiovanni, MN, Godet, J, Horrocks, MH, Tosatto, L, Carr, AR, Wirthensohn, DC, Ranasinghe, RT, Lee, J-E, Ponjavic, A, Fritz, JV, Dobson, CM, Klenerman, D, Lee, SF
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Bongiovanni, M N, Godet, J, Horrocks, M H, Tosatto, L, Carr, A R, Wirthensohn, D C, Ranasinghe, R T, Lee, J, Ponjavic, A, Fritz, J V, Dobson, C M, Klenerman, D & Lee, S F 2016, ' Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping ', Nature Communications, vol. 7, 13544 . https://doi.org/10.1038/ncomms13544
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Bongiovanni, M N, Godet, J, Horrocks, M H, Tosatto, L, Carr, A R, Wirthensohn, D C, Ranasinghe, R T, Lee, J, Ponjavic, A, Fritz, J V, Dobson, C M, Klenerman, D & Lee, S F 2016, ' Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping ', Nature Communications, vol. 7, 13544 . https://doi.org/10.1038/ncomms13544
Super-resolution microscopy allows biological systems to be studied at the nanoscale, but has been restricted to providing only positional information. Here, we show that it is possible to perform multi-dimensional super-resolution imaging to determi
The characterisation of non-native states of proteins is a key problem in studies of protein folding. Complete characterisation of these states requires a description of both local and global properties, including molecular dimensions. Here we presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ec2c0a8ed7a764dc2e85a09d6a3f5fda
https://ora.ox.ac.uk/objects/uuid:c427e1d0-2d86-4d0d-8a23-634a54c69ddc
https://ora.ox.ac.uk/objects/uuid:c427e1d0-2d86-4d0d-8a23-634a54c69ddc
In the presence of 0.5 M NaCl at pH 7.1, the Ca(2+)-free apo form of recombinant bovine alpha-lactalbumin (BLA) is sufficiently stabilised in its native state to give well-resolved NMR spectra at 20 degrees C. The (1)H and (15)N NMR resonances of nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af8bf337b1344b43c0dc427cf44fa319
https://ora.ox.ac.uk/objects/uuid:d28cba53-3f45-4455-a852-e820bf8cf9ee
https://ora.ox.ac.uk/objects/uuid:d28cba53-3f45-4455-a852-e820bf8cf9ee
Reduced denatured lysozyme has been oxidised and refolded at pH values close to neutral in an efficient way by dilution from buffers containing 8.0 M urea, and refolding intermediates were separated by reverse-phase HPLC at pH 2. By using peptic dige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ba0aa833acef9de00c1d142c202dfc4
https://ora.ox.ac.uk/objects/uuid:ae5c1279-e15b-4cf5-a8de-267f14b65fe1
https://ora.ox.ac.uk/objects/uuid:ae5c1279-e15b-4cf5-a8de-267f14b65fe1