Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Dobril Ivanov"'
Autor:
Nuria Martin Flores, Marina Podpolny, Faye McLeod, Isaac Workman, Karen Crawford, Dobril Ivanov, Ganna Leonenko, Valentina Escott-Price, Patricia C Salinas
Publikováno v:
eLife, Vol 12 (2024)
Increasing evidence supports a role for deficient Wnt signaling in Alzheimer’s disease (AD). Studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) colocalizes to amyloid plaques in AD patients. Here, we investigate the contribution of D
Externí odkaz:
https://doaj.org/article/7039ff22efa5466e8bf198b4a028d12c
Autor:
Emily Baker, Rebecca Sims, Ganna Leonenko, Aura Frizzati, Janet C Harwood, Detelina Grozeva, GERAD/PERADES, CHARGE, ADGC, EADI, IGAP consortia, Kevin Morgan, Peter Passmore, Clive Holmes, John Powell, Carol Brayne, Michael Gill, Simon Mead, Paola Bossù, Gianfranco Spalletta, Alison M Goate, Carlos Cruchaga, Wolfgang Maier, Reinhard Heun, Frank Jessen, Oliver Peters, Martin Dichgans, Lutz FröLich, Alfredo Ramirez, Lesley Jones, John Hardy, Dobril Ivanov, Matthew Hill, Peter Holmans, Nicholas D Allen, B Paul Morgan, Sudha Seshadri, Gerard D Schellenberg, Philippe Amouyel, Julie Williams, Valentina Escott-Price
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218111 (2019)
Late onset Alzheimer's disease is the most common form of dementia for which about 30 susceptibility loci have been reported. The aim of the current study is to identify novel genes associated with Alzheimer's disease using the largest up-to-date ref
Externí odkaz:
https://doaj.org/article/ba190fc9ff584d2dad1fe3c08616bffe
Autor:
Lesley Jones, Peter A. Holmans, Marian L. Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R. Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K. Lupton, Carol Brayne, David C. Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S. Brown, Peter A. Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A. David Smith, Seth Love, Patrick G. Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M. Goate, John S. K. Kauwe, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, Gill Livingston, Nicholas J. Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E. Shaw, Andrew B. Singleton, Rita Guerreiro, Thomas W. Mühleisen, Markus M. Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H.-Erich Wichmann, Eckhard Rüther, Minerva M. Carrasquillo, V. Shane Pankratz, Steven G. Younkin, John Hardy, Michael C. O'Donovan, Michael J. Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 6, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/a0c75927ea024e6cbe0463ffa3cddcbf
Autor:
Lesley Jones, Peter A Holmans, Marian L Hamshere, Denise Harold, Valentina Moskvina, Dobril Ivanov, Andrew Pocklington, Richard Abraham, Paul Hollingworth, Rebecca Sims, Amy Gerrish, Jaspreet Singh Pahwa, Nicola Jones, Alexandra Stretton, Angharad R Morgan, Simon Lovestone, John Powell, Petroula Proitsi, Michelle K Lupton, Carol Brayne, David C Rubinsztein, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Kevin Morgan, Kristelle S Brown, Peter A Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Clive Holmes, David Mann, A David Smith, Seth Love, Patrick G Kehoe, Simon Mead, Nick Fox, Martin Rossor, John Collinge, Wolfgang Maier, Frank Jessen, Britta Schürmann, Reinhard Heun, Heike Kölsch, Hendrik van den Bussche, Isabella Heuser, Oliver Peters, Johannes Kornhuber, Jens Wiltfang, Martin Dichgans, Lutz Frölich, Harald Hampel, Michael Hüll, Dan Rujescu, Alison M Goate, John S K Kauwe, Carlos Cruchaga, Petra Nowotny, John C Morris, Kevin Mayo, Gill Livingston, Nicholas J Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam, Panos Deloukas, Ammar Al-Chalabi, Christopher E Shaw, Andrew B Singleton, Rita Guerreiro, Thomas W Mühleisen, Markus M Nöthen, Susanne Moebus, Karl-Heinz Jöckel, Norman Klopp, H-Erich Wichmann, Eckhard Rüther, Minerva M Carrasquillo, V Shane Pankratz, Steven G Younkin, John Hardy, Michael C O'Donovan, Michael J Owen, Julie Williams
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13950 (2010)
BackgroundLate Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in
Externí odkaz:
https://doaj.org/article/f60141a186cd4676b259fd600531e266
Autor:
Nuria Martin-Flores, Marina Podpolny, Faye McLeod, Isaac Workman, Karen Crawford, Dobril Ivanov, Ganna Leonenko, Valentina Escott-Price, Patricia C. Salinas
Increasing evidence supports a role for deficient Wnt signaling in Alzheimer’s disease (AD). Studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) colocalizes to amyloid plaques in AD patients. Here, we investigate the contribution of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3676aa18b0ede3be0e02798ff2bb27da
https://doi.org/10.1101/2022.06.16.495307
https://doi.org/10.1101/2022.06.16.495307
Autor:
Dobril Ivanov, Teresa Niccoli, Linda Partridge, Benjamin Aleyakpo, Inge Snoeren, Daniel K. Fabian, Fiona Kerr, Janet M. Thornton, Oyinkan Sofola-Adesakin, Adam Cryar, Jennifer Adcott
Publikováno v:
Brain Commun
Brain Communications
Brain Communications
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786bea2882571eb2415fc70aaeca055e
https://hdl.handle.net/21.11116/0000-000B-2D76-F
https://hdl.handle.net/21.11116/0000-000B-2D76-F
Autor:
Nathaniel S. Woodling, Jennifer Adcott, Janet M. Thornton, Linda Partridge, Benjamin Aleyakpo, Arjunan Rajasingam, Lauren M. Gittings, Ekin Bolukbasi, Dobril Ivanov, Teresa Niccoli, Andrea Foley
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Significance Aging is the main risk factor for the costliest diseases in today’s world. However, significant gaps remain in understanding how different cell types modulate this most common physiological process. Here, we use published single-cell g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c93bdec9f3299930a3a2647332f53e9
https://eprints.gla.ac.uk/278596/1/278596.pdf
https://eprints.gla.ac.uk/278596/1/278596.pdf
Autor:
Joshua Stevenson-Hoare, Ioanna Katzourou, Thomas W Rowe, Valentina Escott-Price, Dobril Ivanov, Matthew Bracher-Smith
Publikováno v:
Brain Communications
Alzheimer’s disease is a neurodegenerative disorder and the most common form of dementia. Early diagnosis may assist interventions to delay onset and reduce the progression rate of the disease. We systematically reviewed the use of machine learning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddea8870560ba95f19765c457afe23e
https://orca.cardiff.ac.uk/id/eprint/144902/4/fcab246.pdf
https://orca.cardiff.ac.uk/id/eprint/144902/4/fcab246.pdf
Autor:
Sudha Seshadri, John Hardy, Wolfgang Maier, Janet C Harwood, Emily Baker, Carol Brayne, Julie Williams, Lesley Jones, Gerard D. Schellenberg, Reinhard Heun, Frank Jessen, Valentina Escott-Price, Matthew Hill, Oliver Peters, John Powell, Dobril Ivanov, Peter Passmore, Martin Dichgans, Lutz Frölich, Alfredo Ramirez, Aura Frizzati, Alison Goate, Kevin Morgan, Paul Morgan, Carlos Cruchaga, Ganna Leonenko, Gianfranco Spalletta, Paola Bossù, Michael Gill, Clive Holmes, Simon Mead, Detelina Grozeva, Peter Holmans, Philippe Amouyel, Rebecca Sims, Nicholas D. Allen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0218111 (2019)
PLOS ONE 14(7), e0218111 (2019). doi:10.1371/journal.pone.0218111
PLoS ONE, Vol 14, Iss 7, p e0218111 (2019)
PLOS ONE 14(7), e0218111 (2019). doi:10.1371/journal.pone.0218111
A novel POLARIS gene-based analysis approach was employed to compute gene-based polygenic risk score (PRS) for all individuals in the latest HRC imputed GERAD (N cases=3,332 and N controls=9,832) data using the International Genomics of Alzheimer’s
Autor:
Julie Williams, Dobril Ivanov, Janet M. Thornton, Linda Partridge, Gerrit Bostelmann, Benoit Lan-Leung, Valentina Escott-Price
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240824 (2020)
PLoS ONE
PLoS ONE
Many research teams perform numerous genetic, transcriptomic, proteomic and other types of omic experiments to understand molecular, cellular and physiological mechanisms of disease and health. Often (but not always), the results of these experiments