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Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism.

Autor: Grammatika Pavlidou N; Institute of Experimental Cardiovascular Research and University Center of Cardiovascular Sciences, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany., Dobrev S; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany., Beneke K; Institute of Experimental Cardiovascular Research and University Center of Cardiovascular Sciences, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany., Reinhardt F; Institute of Experimental Cardiovascular Research and University Center of Cardiovascular Sciences, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.; Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, O70, 20246 Hamburg, Germany., Pecha S; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.; Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, O70, 20246 Hamburg, Germany., Jacquet E; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France., Abu-Taha IH; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany., Schmidt C; Department of Cardiology, University Medical Center Heidelberg, Im Neuenheimer Feld 672, 69120 Heidelberg, Germany., Voigt N; Institute of Pharmacology and Toxicology, University Medical Center Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.; German Centre for Cardiovascular Research (DZHK), partner Site Göttingen, Potsdamer Strasse 58, 10785 Berlin, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Robert-Koch- Strasse 40, 37075 Göttingen, Germany., Kamler M; Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany., Schnabel RB; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.; Cardiology Department, University Heart and Vascular Centre Hamburg-Eppendorf, Martinistrasse 52, O70, 20246 Hamburg, Germany., Baczkó I; Department Pharmacology and Pharmacotherapy, University of Szeged, H-6721, Szeged, Dóm tér 12, Szeged, Hungary., Garnier A; Inserm, UMR-S 1180, Université Paris-Saclay, Faculté de pharmacie, 17 avenue des Sciences, 91400 Orsay, France., Reichenspurner H; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.; Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, O70, 20246 Hamburg, Germany., Nikolaev VO; Institute of Experimental Cardiovascular Research and University Center of Cardiovascular Sciences, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany., Dobrev D; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 4100 Molson Street, Suite 340, H1Y 3N1 Montréal, Canada.; Department of Molecular Physiology & Biophysics, Baylor College of Medicine, One Baylor Plaza, 77030 Houston, USA., Molina CE; Institute of Experimental Cardiovascular Research and University Center of Cardiovascular Sciences, University Medical Center Hamburg Eppendorf (UKE), Martinistrasse 52, W23, 20246 Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Potsdamer Strasse 58, 10785 Berlin, Germany.; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Hufelandstrasse 55, 45147 Essen, Germany.

Publikováno v: European heart journal [Eur Heart J] 2023 Jul 14; Vol. 44 (27), pp. 2483-2494.