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Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol

Autor: Van Kuijk, K., Mccracken, I., Tillie, R., Asselberghs, S., Kheder, D., Muitjens, S., Jin, H., Taylor, R., Schreur, R. Wichers, Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M., Temmerman, L., Kirkwood, P., Luyten, J., Li, Y., Noels, H., Goossens, P., Wilson-Kanamori, J., Schurgers, L., Shen, Y., Mees, B., Biessen, E., Henderson, N., Kramann, R., Baker, A., Sluimer, J.

Publikováno v: In Atherosclerosis August 2023 379 Supplement 1:S28-S28

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis

Autor: Murray, I. R., Gonzalez, Z. N., Baily, J., Dobie, R., Wallace, R. J., Mackinnon, A. C., Smith, J. R., Greenhalgh, S. N., Thompson, A. I., Conroy, K. P., Griggs, D. W., Ruminski, P. G., Gray, G. A., Singh, M., Campbell, M. A., Kendall, T. J., Dai, J., Li, Y., Iredale, J. P., Simpson, H., Huard, J., Péault, B., Henderson, N. C.

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Murray, I R, Gonzalez, Z N, Baily, J, Dobie, R, Wallace, R J, Mackinnon, A C, Smith, J R, Greenhalgh, S N, Thompson, A I, Conroy, K P, Griggs, D W, Ruminski, P G, Gray, G A, Singh, M, Campbell, M A, Kendall, T J, Dai, J, LI, Y, Iredale, J P, Simpson, H, Huard, J, Péault, B & Henderson, N C 2017, ' αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis ', Nature Communications, vol. 8, 1118 . https://doi.org/10.1038/s41467-017-01097-z
Murray, I R, Gonzalez, Z N, Baily, J, Dobie, R, Wallace, R J, Mackinnon, A C, Smith, J R, Greenhalgh, S N, Thompson, A I, Conroy, K P, Griggs, D W, Ruminski, P G, Gray, G A, Singh, M, Campbell, M A, Kendall, T J, Dai, J, Li, Y, Iredale, J P, Simpson, H, Huard, J, Péault, B & Henderson, N C 2017, ' αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis ', Nature Communications, vol. 8, 1118 . https://doi.org/10.1038/s41467-017-01097-z
Nature Communications

Mesenchymal cells expressing platelet-derived growth factor receptor beta (PDGFRβ) are known to be important in fibrosis of organs such as the liver and kidney. Here we show that PDGFRβ+ cells contribute to skeletal muscle and cardiac fibrosis via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f3ee46da2755b98f711550d1fd0ce4d7
https://doaj.org/article/8d98304aaf1746329d6b32e5bc823995

Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease

Autor: Dobie, R., MacRae, V.E., Pass, C., Milne, E.M., Ahmed, S.F.

Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::acfa3d7b16cd5c89bc564d6fcd5192f4
https://eprints.gla.ac.uk/155624/7/155624.pdf

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