Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dobeen Hwang"'
Autor:
Dobeen Hwang, Christoph Rader
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 764 (2020)
The interest in replacing the conventional immunoglobulin G (IgG) format of monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) with alternative antibody and antibody-like scaffolds reflects a need to expand their therapeutic utility a
Externí odkaz:
https://doaj.org/article/a888354c35df4708881ab6b809cc8ba7
Autor:
Andrew D. Steele, Alexander F. Kiefer, Dobeen Hwang, Dong Yang, Christiana N. Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Publikováno v:
Journal of Medicinal Chemistry. 66:1562-1573
Antibody-drug conjugates (ADCs) are cancer chemotherapeutics that utilize a monoclonal antibody (mAb)-based delivery system, a cytotoxic payload, and a chemical linker. ADC payloads must be strategically functionalized to allow linker attachment with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b902a4c4024f1f9a1c0a68d353992d4
https://doi.org/10.1021/acs.jmedchem.2c01771
https://doi.org/10.1021/acs.jmedchem.2c01771
Autor:
Douglas S. MacPherson, Dobeen Hwang, Samantha M. Sarrett, Outi Keinänen, Cindy Rodriguez, Christoph Rader, Brian M. Zeglis
Publikováno v:
Mol Pharm
Site-specifically modified radioimmunoconjugates exhibit superior in vitro and in vivo behavior compared to analogues synthesized via traditional stochastic methods. However, the development of approaches to site-specific bioconjugation that combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44eaaf5f34f272baab167425e39bbe17
https://doi.org/10.1021/acs.molpharmaceut.2c00700
https://doi.org/10.1021/acs.molpharmaceut.2c00700
Publikováno v:
Bioconjug Chem
Catalytic antibody 38C2 and its humanized version h38C2 harbor a uniquely reactive lysine at the bottom of a 11-Å deep pocket that permits site-specific conjugation of β-diketone-, β-lactam-, and heteroaryl methylsulfonyl-functionalized small and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55822b2272c56bf59ab5c828371ef566
https://europepmc.org/articles/PMC10153793/
https://europepmc.org/articles/PMC10153793/
Autor:
Dong Yang, Fei Ye, Christiana N. Teijaro, Dobeen Hwang, Thibault Annaval, Ajeeth Adhikari, Gengnan Li, Xiaohui Yan, Chun Gui, Christoph Rader, Ben Shen
Publikováno v:
Org Lett
Comparative analyses of four anthraquinone-fused enediyne biosynthetic gene clusters (BGCs) identified YpmL, a cytochrome P450 enzyme, unique to the yangpumicin (YPM) BGC. In vitro characterization of YpmL established it as a hydroxylase, catalyzing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed23097472675b825f86f3040757c44
https://pubmed.ncbi.nlm.nih.gov/35084871
https://pubmed.ncbi.nlm.nih.gov/35084871
Autor:
Douglas MacPherson, Dobeen Hwang, Samantha Sarrett, Cindy Rodriguez, Outi Keinaenen, Christoph Rader, Brian Zeglis
Publikováno v:
Nuclear Medicine and Biology. :S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d97374a04b1ff2ddb1c24122d71ba2d
https://doi.org/10.1016/s0969-8051(22)02119-9
https://doi.org/10.1016/s0969-8051(22)02119-9
Autor:
Dobeen Hwang, Hyori Kim, Dong Hyun Jo, Dongmin Kang, Jeong Hun Kim, Junho Chung, Su Ree Kim, Soohyun Kim
Publikováno v:
Methods. 154:125-135
Antibody selection for antibody-drug conjugates (ADCs) has traditionally depended on its internalization into the target cell, although ADC efficacy also relies on recycling of the receptor-ADC complex, endo-lysosomal trafficking, and subsequent link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3925b46df36dd4de3591a8fd0089e42
https://doi.org/10.1016/j.ymeth.2018.10.002
https://doi.org/10.1016/j.ymeth.2018.10.002
Autor:
Sangyong Jon, Jinjoo Kim, Yujin Kim, Dobeen Hwang, Yonghyun Lee, Dong Yun Lee, Hyeongseop Keum, Hyungjun Kim, Byeongjun Yu, Hyungsu Jeon, Junho Chung
Publikováno v:
Angewandte Chemie. 131:2027-2032
Peptide-based therapeutics have suffered from a short plasma half-life. On the other hand, antibodies suffer from poor penetration into solid tumors owing to their large size. Herein, we present a new molecular form, namely a hybrid complex between a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0aaee443d3178870b939379d2528498
https://doi.org/10.1002/ange.201811509
https://doi.org/10.1002/ange.201811509
Autor:
Sangyong Jon, Dobeen Hwang, So-Young Lee, Yonghyun Lee, Junho Chung, Sunghyun Kim, Minsuk Choi, Sukmo Kang, Hyungjun Kim
Publikováno v:
Molecular Pharmaceutics. 16:165-172
A number of cancer-targeting peptide-drug conjugates (PDCs) have been explored as alternatives to antibody-drug conjugates (ADCs) for targeted cancer therapy. However, the much shorter circulation half-life of PDCs compared with ADCs in vivo has limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b1e8e498efb7537e33be1530bd9b7b
https://doi.org/10.1021/acs.molpharmaceut.8b00924
https://doi.org/10.1021/acs.molpharmaceut.8b00924
Publikováno v:
Bioconjug Chem
By exploiting a uniquely reactive lysine residue (Lys99) for site-specific attachment of small molecules, the humanized catalytic antibody h38C2 has been used as bioconjugation module in the assembly of chemically programmed antibodies and antibody-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e27cdaa0ca5504ece6b256d4331b2ee
https://europepmc.org/articles/PMC7518637/
https://europepmc.org/articles/PMC7518637/