Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures.

Autor: Dave KM; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Stolz DB; Center for Biologic Imaging, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Venna VR; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA., Quaicoe VA; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA., Maniskas ME; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA., Reynolds MJ; Pittsburgh Heart Lung Blood Vascular Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Babidhan R; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Dobbins DX; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Farinelli MN; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA; Department of Biochemistry and Molecular Biology, Gettysburg College, Gettysburg, PA, USA., Sullivan A; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA; Psychological and Brain Sciences, Villanova University, Villanova, PA, USA., Bhatia TN; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Yankello H; Departments of Chemical and Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA., Reddy R; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Bae Y; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Kentucky, Lexington, KY, USA., Leak RK; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA., Shiva SS; Pittsburgh Heart Lung Blood Vascular Institute, University of Pittsburgh Medical School, Pittsburgh, PA, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh Medical School, Pittsburgh, PA, USA., McCullough LD; Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA., Manickam DS; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, USA. Electronic address: soundaramanickd@duq.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Feb; Vol. 354, pp. 368-393. Date of Electronic Publication: 2023 Jan 18.

Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells.

Autor: D'Souza A; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Burch A; Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Dave KM; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Sreeram A; College of William & Mary, Williamsburg, VA, USA., Reynolds MJ; Heart, Lung, Blood Vascular Institute, University of Pittsburgh Medical School, PA, USA., Dobbins DX; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Kamte YS; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Zhao W; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Sabatelle C; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Joy GM; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA., Soman V; Department of Biomedical Informatics, University of Pittsburgh Medical School, PA, USA., Chandran UR; Department of Biomedical Informatics, University of Pittsburgh Medical School, PA, USA., Shiva SS; Heart, Lung, Blood Vascular Institute, University of Pittsburgh Medical School, PA, USA; Department of Pharmacology & Chemical Biology, Pittsburgh Heart Lung Blood Vascular Institute, University of Pittsburgh Medical School, PA, USA., Quillinan N; Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Herson PS; Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Manickam DS; Graduate School of Pharmaceutical Sciences and School of Pharmacy, Duquesne University, Pittsburgh, PA, USA. Electronic address: soundaramanickd@duq.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Oct 10; Vol. 338, pp. 505-526. Date of Electronic Publication: 2021 Aug 24.