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APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.

Autor: Marino C; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Perez-Corredor P; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., O'Hare M; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Heuer A; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Chmielewska N; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Gordon H; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Chandrahas AS; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Gonzalez-Buendia L; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Delgado-Tirado S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Doan TH; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Vanderleest TE; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Arevalo-Alquichire S; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Obar RA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Ortiz-Cordero C; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Villegas A; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Sepulveda-Falla D; Molecular Neuropathology of Alzheimer's Disease, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kim LA; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA., Lopera F; Grupo de Neurociencias de Antioquia, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Mahley R; Gladstone Institute of Neurological Disease, San Francisco, California, USA.; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Medicine, UCSF, San Francisco, California, USA.; Cardiovascular Research Institute, UCSF, San Francisco, California, USA., Huang Y; Gladstone Institute of Neurological Disease, San Francisco, California, USA.; Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurology, UCSF, San Francisco, California, USA., Quiroz YT; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Arboleda-Velasquez JF; Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Feb; Vol. 20 (2), pp. 819-836. Date of Electronic Publication: 2023 Oct 04.