Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities

Autor: Rita Song, Ji Young Lee, Jiyoung Ryu, Young-Mi Kim, Do Yoon Kwon, Hangyeol Jeong, Myung Jin Kim, Inhee Choi, Sangmi Oh

Publikováno v: ACS Med Chem Lett

[Image: see text] This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b4493988f271d8f51387f67e0c0fac
https://europepmc.org/articles/PMC8040044/

Discovery of 4H-chromeno[2,3-d]pyrimidin-4-one derivatives as senescence inducers and their senescence-associated antiproliferative activities on cancer cells using advanced phenotypic assay

Autor: Sangmi Oh, Kwanghan Kong, Seijin Park, Myung Jin Kim, Do Yoon Kwon, Hangyeol Jeong, Young-Mi Kim, Sujin Ahn, Haejin Kwon, Ji Young Lee, Arnaud Ogier, Hwankyu Kang, Inhee Choi, Rita Song, Ulf Nehrbass, Sook Jin Son

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2021, 209, pp.112550-. ⟨10.1016/j.ejmech.2020.112550⟩

Current research suggests therapy-induced senescence (TIS) of cancer cells characterized by distinct morphological and biochemical phenotypic changes represent a novel functional target that may enhance the effectiveness of cancer therapy. In order t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd59b88a5343fdf6c8325aca3d20fb1e
https://doi.org/10.1016/j.ejmech.2020.112550

Eotaxin and monocyte chemotactic protein-3 use different modes of action

Autor: Duck Yeon Lee, Choon-Sik Park, Young Seek Lee, Il Yup Chung, Moon Kyung Choi, Key-Sun Kim, Yong Hyun Kim, Do Yoon Kwon, Yoon Jung Noh, Hun Soo Chang

Publikováno v: Biochemical and Biophysical Research Communications. 314:646-653

Eotaxin selectively binds CC chemokine receptor (CCR) 3, whereas monocyte chemotactic protein (MCP)-3 binds CCR1, CCR2, and CCR3. To identify the functional determinants of the chemokines, we generated four reciprocal chimeric chemokines-M10E9, M22E2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bf3d77225255a02c16ac5b9b923885
https://doi.org/10.1016/j.bbrc.2003.12.134

Contextual automated 3D analysis of subcellular organelles adapted to high-content screening

Autor: Hye Kuyon Lim, Regis Grailhe, Thierry Dorval, Auguste Genovesio, Arnaud Ogier, Howard J. Worman, Do Yoon Kwon, Joohyun Lee, William T. Dauer

Publikováno v: Journal of Biomolecular Screening
Journal of Biomolecular Screening, SAGE Publications, 2010, 15 (7), pp.847-857. ⟨10.1177/1087057110374993⟩
Journal of Biomolecular Screening, 2010, 15 (7), pp.847-857. ⟨10.1177/1087057110374993⟩

Advances in automated imaging microscopy allow fast acquisitions of multidimensional biological samples. Those microscopes open new possibilities for analyzing subcellular structures and spatial cellular arrangements. In this article, the authors des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cb77153388d77331cdf990af63285d
https://pubmed.ncbi.nlm.nih.gov/20639502

Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease

Autor: Doh Kwan Kim, Min Young Seo, Seonwoo Kim, Taegun Kwon, Bernard J. Carroll, Sang Sun Kang, JongWon Kim, Do Yoon Kwon, Shinn-Won Lim

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 25(1)

The protein melanotransferrin (p97) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. We measured serum p97 concentrations in 211 subjects: 71 patients with AD, 56 patients with non-AD-type de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739f8273109b81297c3e3d1ae7868751
https://pubmed.ncbi.nlm.nih.gov/11377921