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Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.

Autor: Aoun M; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Coelho A; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Krämer A; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Saxena A; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Sabatier P; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Beusch CM; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Lönnblom E; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Geng M; Precision Medicine Institute, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China., Do NN; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.; Fraunhofer Institute for Translational Medicine and Pharmacology, and Fraunhofer Cluster of Excellence for Immune-Mediated Diseases , Frankfurt am Main, Germany., Xu Z; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Zhang J; Max Planck Institute Biology of Ageing-Karolinska Institute Laboratory, Karolinska Institute, Solna, Sweden.; Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., He Y; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Romero Castillo L; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Abolhassani H; Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital, Neo Building, Solna, Sweden., Xu B; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Viljanen J; Department of Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden., Rorbach J; Max Planck Institute Biology of Ageing-Karolinska Institute Laboratory, Karolinska Institute, Solna, Sweden.; Division of Molecular Metabolism, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Fernandez Lahore G; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden., Gjertsson I; Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden., Kastbom A; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Sjöwall C; Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Kihlberg J; Department of Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden., Zubarev RA; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.; Department of Pharmacological and Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Burkhardt H; Fraunhofer Institute for Translational Medicine and Pharmacology, and Fraunhofer Cluster of Excellence for Immune-Mediated Diseases , Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany., Holmdahl R; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Sweden.; Precision Medicine Institute, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2023 Nov 06; Vol. 220 (11). Date of Electronic Publication: 2023 Sep 11.

Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.

Autor: Urbonaviciute V; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Romero-Castillo L; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Xu B; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Luo H; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Schneider N; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP 60596 Frankfurt am Main, Germany., Weisse S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP 60596 Frankfurt am Main, Germany., Do NN; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP 60596 Frankfurt am Main, Germany., Oliveira-Coelho A; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Fernandez Lahore G; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Li T; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Sabatier P; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17176 Stockholm, Sweden., Beusch CM; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17176 Stockholm, Sweden., Viljanen J; Department of Chemistry-Biomedicinskt centrum (BMC), Uppsala University 752 37 Uppsala, Sweden., Zubarev RA; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17176 Stockholm, Sweden.; Department of Pharmacological & Technological Chemistry, I. M. Sechenov First Moscow State Medical University 119146 Moscow, Russia., Kihlberg J; Department of Chemistry-Biomedicinskt centrum (BMC), Uppsala University 752 37 Uppsala, Sweden., Bäcklund J; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden., Burkhardt H; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP 60596 Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital Frankfurt, Goethe University 60590 Frankfurt am Main, Germany., Holmdahl R; Division for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute 17177 Stockholm, Sweden.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jun 20; Vol. 120 (25), pp. e2218668120. Date of Electronic Publication: 2023 Jun 12.

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.

Autor: Ge C; Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Weisse S; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Xu B; Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Dobritzsch D; Section of Biochemistry, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Viljanen J; Section of Organic Chemistry, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Kihlberg J; Section of Organic Chemistry, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden., Do NN; Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Schneider N; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Lanig H; Central Institute for Scientific Computing (ZISC), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Erlangen National High Performance Computing Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (current affiliation)., Holmdahl R; Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.; Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China., Burkhardt H; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany Harald.Burkhardt@kgu.de.; Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Frankfurt am Main, Germany.; Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2022 Apr; Vol. 81 (4), pp. 480-489. Date of Electronic Publication: 2022 Jan 13.