Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

Autor: Belén Martinez-Gualda, Mirthe Graus, Anita Camps, Emiel Vanhulle, Sirle Saul, Siavash Azari, Do Hoang Nhu Tran, Laura Vangeel, Winston Chiu, Johan Neyts, Dominique Schols, Shirit Einav, Kurt Vermeire, Steven De Jonghe

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report th

Externí odkaz: https://doaj.org/article/b71621893a6241afbd7e65cfc4b5b2f3

Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii

Autor: Boinett, Christine J, Cain, Amy K, Hawkey, Jane, Do Hoang, Nhu Tran, Khanh, Nhu Nguyen Thi, Thanh, Duy Pham, Dordel, Janina, Campbell, James I, Lan, Nguyen Phu Huong, Mayho, Matthew, Langridge, Gemma C, Hadfield, James, Chau, Nguyen Van Vinh, Thwaites, Guy E, Parkhill, Julian, Thomson, Nicholas R, Holt, Kathryn E, Baker, Stephen

The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::107b434ddd66f7563761ef06226d162e

Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii.

Autor: Boinett CJ; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; 3​Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK., Cain AK; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; 4​Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi., Hawkey J; 5​Centre for Systems Genomics, University of Melbourne, Melbourne, Victoria, Australia.; 6​Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.; 7​Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, Australia., Do Hoang NT; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Khanh NNT; 8​School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia., Thanh DP; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Dordel J; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; 9​Department of Biology, Drexel University, Philadelphia 19104, PA, USA., Campbell JI; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; 3​Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK., Lan NPH; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; 10​Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Mayho M; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Langridge GC; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; 11​Norwich Medical School, University of East Anglia, Norwich, UK., Hadfield J; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Chau NVV; 10​Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites GE; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; 3​Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK., Parkhill J; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Thomson NR; 1​Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; 12​Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Holt KE; 5​Centre for Systems Genomics, University of Melbourne, Melbourne, Victoria, Australia.; 6​Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia., Baker S; 2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; 13​Medicine, The University of Cambridge, Cambridge, UK.; 3​Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.

Publikováno v: Microbial genomics [Microb Genom] 2019 Feb; Vol. 5 (2). Date of Electronic Publication: 2019 Feb 05.