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Polymorphic Pseudogenization of SIGLEC12 in Humans: Relationship to Late Stage Cancer Progression

Autor: Do, Raymond

Publikováno v: Do, Raymond. (2017). Polymorphic Pseudogenization of SIGLEC12 in Humans: Relationship to Late Stage Cancer Progression. UC San Diego: Biology. Retrieved from: http://www.escholarship.org/uc/item/3t2087z4

The primate SIGLEC12 gene encodes one of the CD33-related Siglec family of signaling molecules in immune cells. Siglecs are normally expressed on hematopoietic cells. Interestingly, it was previously reported that the human SIGLEC12 gene product Sigl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::fa99aac8d5df909a34b5885948ee1eb1
http://www.escholarship.org/uc/item/3t2087z4

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Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression.

Autor: Siddiqui SS; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.; Present address: Department of Biotechnology American University of Ras Al Khaimah (AURAK American University of Ras Al Khaimah Road Al Burairat Area Ras Al Khaimah UAE., Vaill M; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Do R; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Khan N; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Verhagen AL; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Zhang W; University of Southern California Norris Comprehensive Cancer Center Los Angeles CA USA., Lenz HJ; University of Southern California Norris Comprehensive Cancer Center Los Angeles CA USA., Johnson-Pais TL; Department of Urology University of TX Health Science Center San Antonio TX USA., Leach RJ; Department of Urology University of TX Health Science Center San Antonio TX USA.; Departments of Cell Systems and Anatomy University of TX Health Science Center San Antonio TX USA., Fraser G; School of Public Health Loma Linda University Loma Linda CA USA., Wang C; School of Public Health Loma Linda University Loma Linda CA USA., Feng GS; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Varki N; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA., Varki A; Departments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.

Publikováno v: FASEB bioAdvances [FASEB Bioadv] 2020 Dec 08; Vol. 3 (2), pp. 69-82. Date of Electronic Publication: 2020 Dec 08 (Print Publication: 2021).