Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dnyandev B. Jarhad"'
Autor:
Woong Sub Byun, Won Kyung Kim, Ji-seong Yoon, Dnyandev B. Jarhad, Lak Shin Jeong, Sang Kook Lee
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 530 (2020)
Triple-negative breast cancer (TNBC) is among the most aggressive and potentially metastatic malignancies. Most affected patients have poor clinical outcomes due to the lack of specific molecular targets on tumor cells. The upregulated expression of
Externí odkaz:
https://doaj.org/article/9eb3267374564edbbdd95f7aaadff61d
Autor:
Young Eum Hyun, Dnyandev B. Jarhad, Minjae Kim, Ayeon Yang, Gyudong Kim, Hong-Rae Kim, Lak Shin Jeong
Publikováno v:
Organic Letters. 24:9281-9284
The conformation of the central five-membered ring of a nucleoside plays an important role in enzyme recognition. Bicyclo[3.1.0]hexane, also known as the methanocarba (MC), serves as a template that can mimic the locked forms of the two distinctive c
Autor:
Anna Shiriaeva, Daejin Park, Gyudong Kim, Yoonji Lee, Xiyan Hou, Dnyandev B. Jarhad, Gibae Kim, Jinha Yu, Young Eum Hyun, Woomi Kim, Zhan-Guo Gao, Kenneth A. Jacobson, Gye Won Han, Raymond C. Stevens, Lak Shin Jeong, Sun Choi, Vadim Cherezov
Publikováno v:
Journal of Medicinal Chemistry. 65:11648-11657
Publikováno v:
Organic Chemistry Frontiers. 9:5536-5543
We have established a catalyst-dependent regioselective Sonogashira coupling methodology where both regioisomeric products can be obtained independently with remarkably high selectivity.
Publikováno v:
Asian Journal of Organic Chemistry. 10:2993-2999
Publikováno v:
The Journal of Organic Chemistry. 84:14414-14426
In search of a new template for anti-hepatitis C virus (HCV) agents, we designed and synthesized the 2'-C-methyl-4'-selenopyrimidine and -purine nucleosides and their phosphoramidate prodrugs to replace a furanose oxygen of anti-HCV nucleos(t)ides wi
Autor:
Sushil Kumar Tripathi, Jessika C. Zevenhoven-Dobbe, Clara C. Posthuma, Lak Shin Jeong, Natacha S. Ogando, Hyuk Woo Lee, Dnyandev B. Jarhad, Eric J. Snijder
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the lack of treatments to combat infections with human or (potentially) zoonotic CoVs. Thus, it is critical to develop and evaluate antiviral compounds that eit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba5ae0fa739b3e7590d5e4322c0c909
https://doi.org/10.1101/2021.05.20.445077
https://doi.org/10.1101/2021.05.20.445077
Autor:
Pramod K. Sahu, Kisu Sung, Dnyandev B. Jarhad, Lak Shin Jeong, Hong-Rae Kim, Dayoung An, Jinha Yu, Young Eum Hyun
Publikováno v:
Asian Journal of Organic Chemistry. 8:1641-1647
Publikováno v:
Archives of Pharmacal Research. 42:780-789
Based on the potent anti-HIV activity of L-2',3'-dideoxycytidine (L-ddC), L-2',3'-dideoxy-4'-selenonucleosides (L-4'-Se-ddNs) have been synthesized from natural chiral template, L-glutamic acid, using Pummerer-type condensation as a key step. All syn
Autor:
Young Eum Hyun, Hong-Rae Kim, Min Hwan Jang, Young Sup Shin, Ji-seong Yoon, Gyudong Kim, Lak Shin Jeong, Dnyandev B. Jarhad
Publikováno v:
Organic Chemistry Frontiers. 6:959-966
Neplanocin A analogs have attracted attention in the fields of biological and medicinal chemistry due to their potent and broad-spectrum antiviral and antitumor activities. To further explore their potential as therapeutic agents, an alternative and