Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Dmytro Ustianenko"'
Autor:
Yocelyn Recinos, Dmytro Ustianenko, Yow-Tyng Yeh, Xiaojian Wang, Martin Jacko, Lekha V. Yesantharao, Qiyang Wu, Chaolin Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated using various drug modalities, including antisense oligonucleotides (ASOs). However, determining promising targets is hampered by the challenge of systemat
Externí odkaz:
https://doaj.org/article/50eafa1abd784c8ab1e55ddaab52c2b2
Autor:
Huijuan Feng, Xiang-Jun Lu, Suvrajit Maji, Linxi Liu, Dmytro Ustianenko, Noam D. Rudnick, Chaolin Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA complexes while our understanding of the photo-crosslinking mechanisms remains poor. This knowledge gap is due to the challenge of precisely mapp
Externí odkaz:
https://doaj.org/article/ba91412f3e74451492761b3a20f6e1bd
Autor:
Sebastien M. Weyn-Vanhentenryck, Huijuan Feng, Dmytro Ustianenko, Rachel Duffié, Qinghong Yan, Martin Jacko, Jose C. Martinez, Marianne Goodwin, Xuegong Zhang, Ulrich Hengst, Stavros Lomvardas, Maurice S. Swanson, Chaolin Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The precise timing of neurodevelopmental splicing switches and the underlying regulatory mechanisms remain poorly understood. This study identifies two major waves of developmental switches under the control of distinct combinations of RNA-binding pr
Externí odkaz:
https://doaj.org/article/e95f34f767ed420686c114eb449248ee
UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA complexes despite our poor understanding on the mechanisms of photo-crosslinking. This knowledge gap is due to the challenge to precisely map the crosslin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a597561de8680843042b995d387b8d79
https://doi.org/10.1101/2022.06.02.494568
https://doi.org/10.1101/2022.06.02.494568
Publikováno v:
Molecular cell. 77(6)
In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein translation. Autism-associated disruption of this exon results in increase
Autor:
Dagmar Zigackova, Josef Pasulka, Mihaela Zavolan, Zuzana Feketova, Dmytro Ustianenko, Lukas Bednarik, Stepanka Vanacova, Andrea Fortova
Publikováno v:
The EMBO Journal
Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are targeted by the 3′ to 5′ exoribonuclease DIS3L2. Mutations in DIS3L2 have been ass
Autor:
Dmytro Ustianenko, Stavros Lomvardas, Martin Jacko, Ulrich Hengst, Xuegong Zhang, Sebastien M. Weyn-Vanhentenryck, Chaolin Zhang, Maurice S. Swanson, Qinghong Yan, Huijuan Feng, Jose C. Martinez, Rachel Duffié, Marianne Goodwin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated during neurodevelopment. However, the precise timing of developmental splicing switches and the underlying regulatory mechanisms are poorly understood. He
Autor:
Sebastien M. Weyn-Vanhentenryck, Pavel Sumazin, Dmytro Ustianenko, Hua-Sheng Chiu, Chaolin Zhang
LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits let-7 microRNAs to regulate development and influence disease states. However, the mechanisms of let-7 suppression remains poorly understood, because LIN28 recognition depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d370cc5c0f1510e280c725ce117dd58
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 8:e1418
The importance of RNA splicing in numerous cellular processes is well established. However, an underappreciated aspect is the ability of the spliceosome to recognize a set of very small (3-30 nucleotide, 1-10 amino acid) exons named microexons. Despi
Autor:
Stjepan Uldrijan, Zbynek Zdrahal, David Potesil, Kristyna Hrazdilova, Dominika Hrossova, Dmytro Ustianenko, Katerina Chalupnikova, Jir̆í Pacherník, Katerina Cetkovska, Stepanka Vanacova
Publikováno v:
RNA
The mechanisms of gene expression regulation by miRNAs have been extensively studied. However, the regulation of miRNA function and decay has long remained enigmatic. Only recently, 3′ uridylation via LIN28A-TUT4/7 has been recognized as an essenti