Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dmytro Khyluk"'
Autor:
Mariia Mishchenko, Sergiy Shtrygol’, Andrii Lozynskyi, Mykhailo Hoidyk, Dmytro Khyluk, Tatyana Gorbach, Roman Lesyk
Publikováno v:
Scientia Pharmaceutica, Vol 90, Iss 3, p 56 (2022)
It was determined that the studied 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) affects the cyclooxygenase pathway of the arachidonic acid cascade, the markers of damage to neurons on models of PTZ kindling. In the m
Externí odkaz:
https://doaj.org/article/82ddb42138e145f5b1f0feaf8f08196b
Autor:
Iryna Ivasechko, Ihor Yushyn, Piotr Roszczenko, Julia Senkiv, Nataliya Finiuk, Danylo Lesyk, Serhii Holota, Robert Czarnomysy, Olga Klyuchivska, Dmytro Khyluk, Nataliya Kashchak, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Rostyslav Stoika, Roman Lesyk
Publikováno v:
Molecules, Vol 27, Iss 19, p 6219 (2022)
Novel pyridine-thiazole hybrid molecules were synthesized and subjected to physico-chemical characterization and screening of their cytotoxic action towards a panel of cell lines derived from different types of tumors (carcinomas of colon, breast, an
Externí odkaz:
https://doaj.org/article/b7c986c8e0ab406bb5299519122d24d4
Publikováno v:
Molbank, Vol 2021, Iss 2, p M1211 (2021)
The small pyrazolone-bearing molecules attract attention and are widely explored in drug design as pharmacological agents. The new pyrazolone-thiadiazole hybrid molecule N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[[5-[(1,5-dimethyl-3-oxo-2-ph
Externí odkaz:
https://doaj.org/article/77944ec4215a4265811d25cab9b7fcea
Autor:
Andrii Lozynskyi, Yulian Konechnyi, Julia Senkiv, Ihor Yushyn, Dmytro Khyluk, Olexandr Karpenko, Yulia Shepeta, Roman Lesyk
Publikováno v:
Scientia Pharmaceutica, Vol 89, Iss 4, p 52 (2021)
A series of 5-methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones has been designed, synthesized, and characterized by spectral data. Target compounds were screened for their antimicrobial activity against some pathogenic bacteria and fungi, and most of
Externí odkaz:
https://doaj.org/article/0b0d0feb7fcb4c23b64219c7ad467f6c
Publikováno v:
Problems of Chemistry and Sustainable Development. :61-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30325912c61a9705717139604258976a
https://doi.org/10.32782/pcsd-2022-2-8
https://doi.org/10.32782/pcsd-2022-2-8
Autor:
Iryna Ivasechko, Andrii Lozynskyi, Julia Senkiv, Piotr Roszczenko, Yuliia Kozak, Nataliya Finiuk, Olga Klyuchivska, Nataliya Kashchak, Nazar Manko, Zvenyslava Maslyak, Danylo Lesyk, Andriy Karkhut, Svyatoslav Polovkovych, Robert Czarnomysy, Olga Szewczyk, Andriy Kozytskiy, Olexandr Karpenko, Dmytro Khyluk, Andrzej Gzella, Krzysztof Bielawski, Anna Bielawska, Petr Dzubak, Sona Gurska, Marian Hajduch, Rostyslav Stoika, Roman Lesyk
Publikováno v:
European Journal of Medicinal Chemistry. 252:115304
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33f781e6884f71f3caf5aec397be77c
https://doi.org/10.1016/j.ejmech.2023.115304
https://doi.org/10.1016/j.ejmech.2023.115304
Autor:
Ihor Yushyn, Roman Lesyk, Olexandr Karpenko, Yulian Konechnyi, Julia Senkiv, Yulia Shepeta, Dmytro Khyluk, Andrii Lozynskyi
Publikováno v:
Scientia Pharmaceutica; Volume 89; Issue 4; Pages: 52
Scientia Pharmaceutica, Vol 89, Iss 52, p 52 (2021)
Scientia Pharmaceutica, Vol 89, Iss 52, p 52 (2021)
A series of 5-methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones has been designed, synthesized, and characterized by spectral data. Target compounds were screened for their antimicrobial activity against some pathogenic bacteria and fungi, and most of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a386e6a7e7fd67d49b193a0b97a5ff
Autor:
Monika Bar, Bartosz Skóra, Anna Tabęcka-Łonczyńska, Serhii Holota, Dmytro Khyluk, Olexandra Roman, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Bioorganic Chemistry. 128:106075
Development of cancer drug-resistance is still an ongoing problem in the modern anticancer treatment. Therefore, there is a need to search for a new active substance, which may become a potential anticancer agent. 4-Thiazolidinones are well-described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869928ad5080d62d0ac3d565ad6f992e
https://doi.org/10.1016/j.bioorg.2022.106075
https://doi.org/10.1016/j.bioorg.2022.106075
Autor:
Bartosz Skóra, Danylo Kaminskyy, Konrad A. Szychowski, Dmytro Khyluk, Roman Lesyk, Anna Kryshchyshyn-Dylevych
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111684-(2021)
PPARγ regulate the expression of genes involved in peripheral insulin sensitivity, adipogenesis, and glucose homeostasis. Moreover, PPARγ agonists, such as pioglitazone and rosiglitazone, are used in the treatment of various diseases, e.g. diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d3f0047559bf50e903d8b375440b0a
https://doi.org/10.1016/j.biopha.2021.111684
https://doi.org/10.1016/j.biopha.2021.111684
Publikováno v:
Scientia Pharmaceutica
Volume 79
Issue 4
Pages 763-778
Volume 79
Issue 4
Pages 763-778
The synthesis and evaluation of the anticancer activity of 3'-aryl-5'-arylidene-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-diones and spiro[3H-indole-3,2'-thi-azolidine]-2,4'(1H)-dione-3'-alkanoic acid esters were described. The structure of the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6bc5513d1e79220b376728820a872d
https://doi.org/10.3797/scipharm.1109-14
https://doi.org/10.3797/scipharm.1109-14