Výsledky vyhledávání - "Dmytro Kagan"

Plasma Membrane Density of GABAB-R1a, GABAB-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex

Autor: Petr Svoboda, Hana Ujcikova, Dmytro Kagan, K Dlouhá, Lenka Roubalova

Publikováno v: ResearcherID
Publons
Europe PubMed Central

With the aim to understand the onset of expression and developmental profile of plasma membrane (PM) content /density of crucial components of GABA(B)-R signaling cascade, GABA(B)-R1a, GABA(B)-R1b, GABA(B)-R2, G(i)1/G(i)2alpha, G(i)3alpha, G(o)alpha,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3529188c2cf23cdb8937d3c79f37c1
https://doi.org/10.33549/physiolres.932552

Zobrazit plný text záznamu

Ontogenetic Development of GABAB-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABAB-Receptors Is High Already Shortly After the Birth

Autor: Dmytro Kagan, Lenka Roubalova, K Dlouhá, Petr Svoboda

Publikováno v: ResearcherID
Publons

Our data indicate the significant intrinsic efficacy of GABA(B)-receptors in rat brain cortex already at birth (PD1, PD2). Subsequently, baclofen- and SKF97541-stimulated G-protein activity, measured by agonist-stimulated, high-affinity [(35)S]GTPgam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465f98425874de27d3837b383b325627
https://doi.org/10.33549/physiolres.932358

Zobrazit plný text záznamu

Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments

Autor: Joško Ivica, Dmytro Kagan, J. Wilhelm, Petr Svoboda

Publikováno v: Molecular and Cellular Biochemistry. 347:157-162

The increased generation of free radicals results in the formation of fluorescent end-products of lipid peroxidation, lipofuscin-like pigments (LFPs). The authors observed that LFPs are generated in rat brain after a normal birth during 5 postnatal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cd3a246696ae29bbcbd29b49a62372
https://doi.org/10.1007/s11010-010-0623-2

Zobrazit plný text záznamu

Opioid-receptor (OR) signaling cascades in rat cerebral cortex and model cell lines: the role of plasma membrane structure

Autor: Martin Hof, Pavel Ostasov, Jan Sýkora, Dmytro Kagan, Marco Parenti, Ladislav Merta, Lenka Roubalova, Jana Brejchova, Novotný J, K Dlouhá, Miroslava Vosahlikova, Petr Svoboda, Hana Ujcikova, Z. Drastichová

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE
Publons
ResearcherID
Europe PubMed Central

Large number of extracellular signals is received by plasma membrane receptors which, upon activation, transduce information into the target cell interior via trimeric G-proteins (GPCRs) and induce activation or inhibition of adenylyl cyclase enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4d5ca3582591176e8e568219206ad3
https://pubmed.ncbi.nlm.nih.gov/24564656

Zobrazit plný text záznamu

Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal

Autor: Hana Ujcikova, Lenka Roubalova, Miroslava Vosahlikova, K Dlouhá, Petr Svoboda, Dmytro Kagan

Publikováno v: Biochimica et biophysica acta. 1810(12)

Background Activation of adenylyl cyclase (AC) by prolonged exposure of mammalian organism to morphine was demonstrated in previous studies of mechanism of action of this drug. However, expression level of individual AC isoforms was not analyzed in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92af30db67d9f33b581358cc569cb6b6
https://pubmed.ncbi.nlm.nih.gov/22001437

Zobrazit plný text záznamu

Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits

Autor: Lenka, Bourova, Miroslava, Vosahlikova, Dmytro, Kagan, Katerina, Dlouha, Jiri, Novotny, Petr, Svoboda

Publikováno v: Medical science monitor : international medical journal of experimental and clinical research. 16(8)

The functional activity of trimeric guanine-nucleotide-binding proteins (G-proteins) represents an essential step in linking and regulation of the opioid receptor (mu-, delta- and kappa-OR)-initiated signaling pathways. Theoretical basis and/or molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bfb34fcf5d22866bda47d479a1b4ef9
https://pubmed.ncbi.nlm.nih.gov/20671607

Zobrazit plný text záznamu

Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine

Autor: Lenka Roubalova, Adam Eckhardt, Hana Ujcikova, Dmytro Kagan, Petr Svoboda

Publikováno v: Proteome Science

Background Proteomic analysis was performed in post-nuclear supernatant (PNS) and Percoll-purified membranes (PM) prepared from fore brain cortex of rats exposed to increasing doses of morphine (10–50 mg/kg) for 10 days. Results In PNS, the 10 up (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea9d89d83c8b37355f62069174c5fb0

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání