Výsledky vyhledávání - "Dmitry Solomon"

Heterobifunctional Multivalent Inhibitor-Adaptor Mediates Specific Aggregation between Shiga Toxin and a Pentraxin

Autor: Dmitry Solomon, Gordon Grant, Eugenia Paszkiewicz, Pavel I. Kitov, David R. Bundle, Joanna M. Sadowska

Publikováno v: Organic Letters. 7:4369-4372

The first example of a multivalent heterofunctional inhibitor-adaptor, called “BAIT”, is described. This multivalent inhibitor-adaptor is able to capture a “target” receptor (Shiga toxin) through i...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9ce7ef9690ec3002af4d1690f1ec2e8
https://doi.org/10.1021/ol051529+

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Detailed Kinetic Analysis and Identification of the Nucleophile in α-l-Arabinofuranosidase from Geobacillus stearothermophilus T-6, a Family 51 Glycoside Hydrolase

Autor: D. Shallom, Dmitry Solomon, Yuval Shoham, Timor Baasov, Valery Belakhov, Gil Shoham

Publikováno v: Journal of Biological Chemistry. 277:43667-43673

alpha-l-Arabinofuranosidases cleave the l-arabinofuranoside side chains of different hemicelluloses and are key enzymes in the complete degradation of the plant cell wall. The alpha-l-arabinofuranosidase from Geobacillus stearothermophilus T-6, a fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f29472cbc9e127a92305f89275a7175
https://doi.org/10.1074/jbc.m208285200

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The identification of the acid-base catalyst of α-arabinofuranosidase fromGeobacillus stearothermophilusT-6, a family 51 glycoside hydrolase

Autor: D. Shallom, Yuval Shoham, Valery Belakhov, Gil Shoham, Dmitry Solomon, Timor Baasov, Sara Gilead-Gropper

Publikováno v: FEBS Letters. 514:163-167

The α-L-arabinofuranosidase from Geobacillus stearothermophilus T-6 (AbfA T-6) belongs to the retaining family 51 glycoside hydrolases. The conserved Glu175 was proposed to be the acid–base catalytic residue. AbfA T-6 exhibits residual activity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63d63f08ba102f040a90089ed597245
https://doi.org/10.1016/s0014-5793(02)02343-8

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A Synthetic Pentasaccharide with GTPase Activity

Autor: and Jeanwei Zhang, Micha Fridman, Dmitry Solomon, Timor Baasov

Publikováno v: Organic Letters. 3:4311-4314

The design, synthesis, and preliminary evaluation of the first example of synthetic pentasaccharide (1) that shows marked rate enhancement and specificity for the hydrolysis of GTP to GDP and orthophosphate (OP) are reported. At the concentration rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0db36fc7ca4a192fcc3fe0b54169d1a
https://doi.org/10.1021/ol010257h

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Stereochemistry of family 52 glycosyl hydrolases: a β-xylosidase fromBacillus stearothermophilusT-6 is a retaining enzyme

Autor: Valery Belakhov, Dmitry Solomon, Yuval Shoham, Smadar Shulami, Timor Baasov, Gil Shoham, Gennady Zolotnitsky, Tsafrir Bravman

Publikováno v: FEBS Letters. 495:39-43

A beta-xylosidase from Bacillus stearothermophilus T-6 assigned to the uncharacterized glycosyl hydrolase family 52 was cloned, overexpressed in Escherichia coli and purified. The enzyme showed maximum activity at 65 degrees C and pH 5.6-6.3. The ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b136b4052cd8cb573ff16b3b1e09ee
https://doi.org/10.1016/s0014-5793(01)02360-2

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One-Pot Synthesis of Glucosamine Oligosaccharides

Autor: Dmitry Solomon, Shay Yogev, Timor Baasov, Micha Fridman

Publikováno v: Organic Letters. 4:281-283

[reaction: see text] Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8852f56ba57ffbfbe516c42b30142a
https://doi.org/10.1021/ol017054d

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ChemInform Abstract: One-Pot Synthesis of Glucosamine Oligosaccharides

Autor: Dmitry Solomon, Timor Baasov, Shay Yogev, Micha Fridman

Publikováno v: ChemInform. 33

Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ed951cf42d05eb864733b26741d790d
https://doi.org/10.1002/chin.200221157

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Heterobifunctional multivalent inhibitor-adaptor mediates specific aggregation between Shiga toxin and a pentraxin

Autor: Dmitry, Solomon, Pavel I, Kitov, Eugenia, Paszkiewicz, Gordon A, Grant, Joanna M, Sadowska, David R, Bundle

Publikováno v: Organic letters. 7(20)

[reaction: see text] The first example of a multivalent heterofunctional inhibitor-adaptor, called "BAIT", is described. This multivalent inhibitor-adaptor is able to capture a "target" receptor (Shiga toxin) through its recognition of one ligand of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::932321ff667de868181d2c1e63bb8d08
https://pubmed.ncbi.nlm.nih.gov/16178535

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