Výsledky vyhledávání - "Dmitry Samarsky"

Potent and systematic RNAi mediated silencing with single oligonucleotide compounds

Autor: Jessica T. Lam, Jennifer Lapierre, Anastasia Khvorova, Bernice Smith-Anzures, Tod M. Woolf, Dmitry Samarsky, Karen Bulock, Glenna Ford, Joanne Kamens, William Salomon, James Cardia, William Stanney

Publikováno v: RNA. 17:1032-1037

RNA interference (RNAi) has been established as an important tool for functional genomics studies and has great promise as a therapeutic intervention for human diseases. In mammalian cells, RNAi is conventionally induced by 19–27-bp RNA duplexes ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0bd0f3b8b502e7197e8ba93f409843
https://doi.org/10.1261/rna.2399411

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Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA

Publikováno v: Nucleic Acids Research

RNAi technology is taking strong position among the key therapeutic modalities, with dozens of siRNA-based programs entering and successfully progressing through clinical stages of drug development. To further explore potentials of RNAi technology as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a51abe9053a2ae76101bd57f80f6982
https://pubmed.ncbi.nlm.nih.gov/25223783

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A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiency

Autor: Robert Cedergren, Edouard Bertrand, Maurille J. Fournier, Dmitry Samarsky, Robert H. Singer, Gerardo Ferbeyre

Publikováno v: Proceedings of the National Academy of Sciences. 96:6609-6614

A hammerhead ribozyme has been localized to the yeast nucleolus by using the U3 small nucleolar RNA as a carrier. The hybrid small nucleolar RNA:ribozyme, designated a “snorbozyme,” is metabolically stable and cleaves a target U3 RNA with nearly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4661a063a3c5a3666c8cdfba29db0e
https://doi.org/10.1073/pnas.96.12.6609

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A comprehensive database for the small nucleolar RNAs from Saccharomyces cerevisiae

Autor: Dmitry Samarsky, Maurille J. Fournier

Publikováno v: Nucleic Acids Research. 27:161-164

Small nucleolar RNAs (snoRNAs) are involved in cleavage of rRNA, modification of rRNA nucleotides and, perhaps, other aspects of ribosome biogenesis in eukaryotic cells. Scores of snoRNAs have been discovered in recent years from various eukaryotes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5859cd2487e2b6be8d51a0941d553e0d
https://doi.org/10.1093/nar/27.1.161

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An essential domain in Saccharomyces cerevisiae U14 snoRNA is absent in vertebrates, but conserved in other yeasts

Autor: Maurille J. Fournier, Gregory S. Schneider, Dmitry Samarsky

Publikováno v: Nucleic Acids Research. 24:2059-2066

U14 is a small nucleolar RNA (snoRNA) required for early cleavages of eukaryotic precursor rRNA. The U14 RNA from Saccharomyces cerevisiae is distinguished from its vertebrate homologues by the presence of a stem-loop domain that is essential for fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3862292e8a17d9ca31596be44d3e4ed
https://doi.org/10.1093/nar/24.11.2059

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Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments

Autor: Céline Verheggen, Jean-Marie Blanchard, John Mouaikel, Rémy Bordonné, Edouard Bertrand, Dmitry Samarsky, Denis L. J. Lafontaine

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2002, 21 (11), pp.2736--45. ⟨10.1093/emboj/21.11.2736⟩
EMBO Journal, 2002, 21 (11), pp.2736--45. ⟨10.1093/emboj/21.11.2736⟩

Nucleolar localization of vertebrate box C/D snoRNA involves transit through Cajal bodies, but the significance of this event is unknown. To define better the function of this compartment, we analyzed here the maturation pathway of mammalian U3. We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9982c29a4357fcad51242ccbb6d4578
https://europepmc.org/articles/PMC126019/

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An unexpected, conserved element of the U3 snoRNA is required for Mpp10p association

Autor: Maurille J. Fournier, Susan J. Baserga, Steven Wormsley, Dmitry Samarsky

The U3 small nucleolar ribonucleoprotein (snoRNP) is composed of a small nucleolar RNA (snoRNA) and at least 10 proteins. The U3 snoRNA base pairs with the pre-rRNA to carry out the A0, A1, and A2 processing reactions that lead to the release of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93eb7e8bf20c1f49030906f4de46a3da
https://europepmc.org/articles/PMC1370138/

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Intronic snoRNA biosynthesis in Saccharomyces cerevisiae depends on the lariat-debranching enzyme: intron length effects and activity of a precursor snoRNA

Autor: Jef D. Boeke, Maurille J. Fournier, Dmitry Samarsky, Siew Loon Ooi

Publikováno v: RNA (New York, N.Y.). 4(9)

The eukaryotic small nucleolar RNAs (snoRNAs) are involved in processing of pre-rRNA and modification of rRNA nucleotides. Some snoRNAs are derived from mono- or polycistronic transcription units, whereas others are encoded in introns of protein gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331a270820776522b306c4f35912ace9
https://pubmed.ncbi.nlm.nih.gov/9740128

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