Expression of p53 Protein Associates with Anti-PD-L1 Treatment Response on Human-Derived Xenograft Model of GATA3/CR5/6-Negative Recurrent Nonmuscular Invasive Bladder Urothelial Carcinoma

Autor: Ekaterina Blinova, Elena Samishina, Olga Deryabina, Dmitry Blinov, Dmitry Roshchin, Evgeniia Shich, Oxana Tumutolova, Ilya Fedoseykin, Anna Epishkina, Haydar Barakat, Andrey Kaprin, Kirill Zhandarov, Dmitrij Perepechin, Dmitrij Merinov, Gordey Brykin, Karen Arutiunian, Stanislav Serebrianyi, Artem Mirontsev, Andrew Kozdoba

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 18, p 9856 (2021)

Background: The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 exp

Externí odkaz: https://doaj.org/article/287dc68fa166405ea247c9153103b21c

Patient-Derived Non-Muscular Invasive Bladder Cancer Xenografts of Main Molecular Subtypes of the Tumor for Anti-Pd-l1 Treatment Assessment

Autor: Ekaterina Blinova, Dmitry Roshchin, Evgenya Kogan, Elena Samishina, Tatiana Demura, Olga Deryabina, Irina Suslova, Dmitry Blinov, Pavel Zhdanov, Usif Osmanov, Mikhail Nelipa, Andrey Kaprin

Publikováno v: Cells, Vol 8, Iss 6, p 526 (2019)

Background: Establishment of heterotopic patient-derived xenografts of primary and relapsed non-muscular invasive bladder cancer (NMIBC) to explore the biological property of PD-L1 signaling that may impact bladder tumor growth in humanized animals.

Externí odkaz: https://doaj.org/article/88759f77241a428c8e02983fe62e1dff

Prognostic Role of FGFR3 Expression Status and Tumor-Related MicroRNAs Level in Association with PD-L1 Expression in Primary Luminal Non-Muscular Invasive Bladder Carcinoma

Autor: Anton Buzdin, Natalia V Potoldykova, Elena Samyshina, Pieter Borger, Evgenia Shich, Maria Suntsova, Dmitry Enikeev, Oxana Tumutolova, Dmitry Roshchin, Aleksey Drobyshev, V.A. Grigoryan, Dmitrij Merinov, Olga Deryabina, Haydar Barakat, E V Blinova, Dmitrij Perepechin, Stanislav Serebrianyi, D S Blinov, Aleksandr Kachmazov, Pavel Zhdanov, Tatiana Demura

Publikováno v: Life, Vol 10, Iss 305, p 305 (2020)
Life
Volume 10
Issue 11

Background: bladder cancer is one of the most common urinary tract malignancies. Establishment of robust predictors of disease progression and outcome is important for personalizing treatment of non-muscular invasive bladder carcinoma (NMIBC). In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3532bff58081880bdf604987e2944e85
https://www.mdpi.com/2075-1729/10/11/305

Relapse-Free Survival and PD-L1 Expression in First High- and Low-Grade Relapsed Luminal, Basal and Double-Negative P53-Mutant Non-Muscular Invasive Bladder Cancer Depending on Previous Chemo- and Immunotherapy

Autor: Haydar Barakat, Aleksandr Kachmazov, Elena Samyshina, Dmitrij Perepechin, E V Blinova, Evgenia Kogan, Aleksander Tertychnyy, Stanislav Serebrianyi, Marina O. Dudina, Natalia V Potoldykova, Dmitry Enikeev, D S Blinov, Olga Deryabina, Dmitry Roshchin, Dmitrij Merinov

Publikováno v: Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1316, p 1316 (2020)

The goal of this study was to assess how PD-L1 expression in tissue specimens of patients with main molecular subtypes of NMIBC (luminal, basal and double-negative p53-mutant) associates with relapsed-free survival in dependence on the tumor grade an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac656b37c1c222e4f0e86c1329cf01f3

Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice

Autor: Marina O. Dudina, Dmitry Roshchin, D S Blinov, E V Blinova, Irina R Suslova, Elena Samishina

Publikováno v: Journal of Advanced Pharmaceutical Technology & Research, Vol 9, Iss 4, Pp 130-134 (2018)
Journal of Advanced Pharmaceutical Technology & Research

2-Amino-4H-chromene derivatives possess anticancer property proved on different in vivo and in vitro models of malignancies such breast, nasopharyngeal, bladder, ovary carcinomas, astrocytoma, and osteosarcoma. We assumed it might be effective to app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d877a9e28e6431acb039f21d1ee54f4
http://www.japtr.org/article.asp?issn=2231-4040