Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Dmitry O, Koltun"'
Autor:
Jiri Vlach, Alexandra B. Samal, Anita Niedziela-Majka, Michael V. Lee, Giuseppe A. Papalia, Melanie H. Wong, Katherine M. Brendza, Brian E. Schultz, Dmitry O. Koltun, Hyock Joo Kwon, Joy Y. Feng, Roman Sakowicz, Nikolai Novikov, Jamil S. Saad
Publikováno v:
Journal of Molecular Biology. 431:1440-1459
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca2+/CaM) through a direct bin
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Autor:
Melanie H, Wong, Alexandra B, Samal, Mike, Lee, Jiri, Vlach, Nikolai, Novikov, Anita, Niedziela-Majka, Joy Y, Feng, Dmitry O, Koltun, Katherine M, Brendza, Hyock Joo, Kwon, Brian E, Schultz, Roman, Sakowicz, Jamil S, Saad, Giuseppe A, Papalia
Publikováno v:
Journal of molecular biology. 431(7)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca
Autor:
Jeff A, Zablocki, Elfatih, Elzein, Xiaofen, Li, Dmitry O, Koltun, Eric Q, Parkhill, Tetsuya, Kobayashi, Ruben, Martinez, Britton, Corkey, Haibo, Jiang, Thao, Perry, Rao, Kalla, Gregory T, Notte, Oliver, Saunders, Michael, Graupe, Yafan, Lu, Chandru, Venkataramani, Juan, Guerrero, Jason, Perry, Mark, Osier, Robert, Strickley, Gongxin, Liu, Wei-Qun, Wang, Lufei, Hu, Xiao-Jun, Li, Nesrine, El-Bizri, Ryoko, Hirakawa, Kris, Kahlig, Cheng, Xie, Cindy Hong, Li, Arvinder K, Dhalla, Sridharan, Rajamani, Nevena, Mollova, Daniel, Soohoo, Eve-Irene, Lepist, Bernard, Murray, Gerry, Rhodes, Luiz, Belardinelli, Manoj C, Desai
Publikováno v:
Journal of medicinal chemistry. 59(19)
Late sodium current (late I
Publikováno v:
ChemInform. 26
A short pathway for the stereocontrolled synthesis of the title compounds from readily available precursors is elaborated which involves as a key step a stereoselective Pauson-Khand cyclization of the substrates of trans-2-allyl-1-ethynylcyclopentano
Autor:
Dmitry O. Koltun, Timur M. Zilbershtein, Vasily A. Migulin, Natalya I. Vasilevich, Eric Q. Parkhill, Andrei I. Glushkov, Malcolm J. McGregor, Sandra A. Brunn, Nancy Chu, Jia Hao, Nevena Mollova, Kwan Leung, Jeffrey W. Chisholm, Jeff Zablocki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Two structurally distinct series of SCD (Delta9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the structural features of the two series. This led to the discovery of compound 5b (CVT-12,01
Autor:
Dmitry O. Koltun, et al. et al.
Publikováno v:
ChemInform. 35