Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dmitry N. Derkach"'
Autor:
Colleen Ziegler, Alain Mir, Sangeetha Anandakrishnan, Patrick Martin, Elma Contreras, Isaiah Slemons, Barbara Witkowski, Chris DeSilva, Andrew Farmer, Semir Vranic, Zoran Gatalica, David Richardson, Dmitry N. Derkach
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 1953-1961 (2023)
The role of the tumor microenvironment (TME) in immuno‐oncology has driven demand for technologies that deliver in situ, or spatial, molecular information. Compartmentalized heterogeneity that traditional methods miss is becoming key to predicting
Externí odkaz:
https://doaj.org/article/3923b614bd924306b7a85645acc777c0
Autor:
Semir Vranic, Elma Contreras, David S. Richardson, Colleen Ziegler, Chris DeSilva, Andrew Farmer, Alain Mir, Barbara Witkowski, Zoran Gatalica, Sangeetha Anandakrishnan, Isaiah Slemons, Dmitry N. Derkach
Breast cancer consists of several intrinsic molecular subtypes, providing the basis for clinical treatment decisions. Lately, it is becoming increasingly recognized that factors other than the intrinsic cancer characteristics, such as immune componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0c66111e5ef4de3b442ba5081f4e2c
https://hdl.handle.net/10576/12392
https://hdl.handle.net/10576/12392
RGD-dependent binding of TP508 to integrin αvβ3 mediates cell adhesion and induction of nitric oxide
Autor:
Kim B. Perkins, Michael R. Sheller, Catherine M. Dreiza, Tatiana P. Ugarova, Dmitry N Derkach, Heidi C Ramos, Subhagya A Wadekar, Emma Rousseau, Joyce Cheung-Flynn
Publikováno v:
Thrombosis and Haemostasis. 104:172-182
SummaryP508, a 23-amino acid RGD-containing synthetic peptide representing residues 508 to 530 of human prothrombin, mitigates the effects of endothelial dysfunction in ischaemic reperfusion injury. The objective of this study was to investigate whet
Publikováno v:
Molecular and Cellular Biochemistry. 248:105-114
The contraction of smooth muscle is regulated primarily by intracellular Ca2+ signal. It is well established that the elevation of the cytosolic Ca2+ level activates myosin light chain kinase, which phosphorylates 20 kDa regulatory myosin light chain
Autor:
Junji Nishimura, Eikichi Ihara, Hideo Kanaide, Katsuya Hirano, Hajime Nawata, Dmitry N. Derkach
Publikováno v:
The Journal of Physiology. 534:701-711
1. To determine the mechanism of bradykinin-induced production of endothelium-derived contracting factors, we monitored the changes in cytosolic Ca(2+) concentration ([Ca(2+)](i)) in in situ endothelial cells in porcine aortic valvular strips and the
Autor:
Hideo Kanaide, Dmitry N. Derkach, Eikichi Ihara, Junji Nishimura, Shosuke Takahashi, Katsuya Hirano
Publikováno v:
British Journal of Pharmacology. 131:1635-1642
Using a method employing front-surface fura-2 fluorometry to measure the cytosolic Ca2+ concentration, [Ca2+]i, the mechanism of endothelium-dependent regulation of vascular tone by thrombin was studied in porcine renal interlobar arterial strips. At
Publikováno v:
Anesthesia & Analgesia. 91:1066-1072
More than 50% of patients suffer neuropsychologic impairment after cardiac surgery. We measured neuron-specific enolase (NSE) and S-100 protein (S-100) in patients' serum as putative markers of neuronal and astroglial cell injury, respectively. Group
Autor:
Eikichi Ihara, Hajime Nawata, Katsuya Hirano, Dmitry N. Derkach, Hideo Kanaide, Junji Nishimura
Publikováno v:
British Journal of Pharmacology. 129:943-952
The mechanism of endothelium-dependent regulation of vascular tone of bradykinin was investigated by simultaneously monitoring the changes in the cytosolic Ca2+ concentration and the force of smooth muscle in fura-2-loaded strips of the porcine renal
Autor:
Hideo Kanaide, Shosuke Takahashi, Katsuya Hirano, Junji Nishimura, Mayumi Hirano, Dmitry N. Derkach
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 24(3)
Objective— The region of the 110 kDa regulatory subunit (MYPT1) of smooth muscle myosin phosphatase involved in the regulation of contraction was determined under physiological conditions. Methods and Results— Using HIV Tat protein-mediated prote
Publikováno v:
Molecular and cellular biochemistry. 248(1-2)
The contraction of smooth muscle is regulated primarily by intracellular Ca2+ signal. It is well established that the elevation of the cytosolic Ca2+ level activates myosin light chain kinase, which phosphorylates 20 kDa regulatory myosin light chain