Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dmitry M. Volochnyuk"'
Autor:
Oleksandr V. Oksiuta, Alexander E. Pashenko, Radomyr V. Smalii, Dmitry M. Volochnyuk, Serhii V. Ryabukhin
Publikováno v:
Журнал органічної та фармацевтичної хімії, Vol 21, Iss 1, Pp 3-19 (2023)
Aim. DNA-encoded libraries technologies (DELT) are gradually becoming an important part of standard drug discovery toolbox. DELT is looking to find its place between classic low-molecular-weight drug candidates on the one hand, and high-molecular-wei
Externí odkaz:
https://doaj.org/article/b8a205e657b04a6b81a395f328cea39f
Publikováno v:
New Journal of Chemistry. 42:8355-8365
Analysis of disubstituted heteroaliphatic, as well as all common saturated rings using the exit vector plots (EVPs) tool is described, which is based on the Cambridge Structural Database (CSD) data. It is shown that the combined EVPs for saturated ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f242ab6f7ca5afde9cd5d713c43795e5
https://doi.org/10.1039/c7nj05015a
https://doi.org/10.1039/c7nj05015a
Autor:
Dmitry M. Volochnyuk, Oleksandr O. Grygorenko, Igor V. Komarov, Oleksii Raievskyi, Pavlo Babenko
Publikováno v:
RSC Advances. 6:17595-17605
An approach to the analysis and visualization of chemical space covered by disubstituted scaffolds, which is based on exit vector plots (EVPs), is used for analysis of the simplest disubstituted cyclic cores – cycloalkanes – deposited in the Camb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c944f98071a05b366974ec805c9f03
https://doi.org/10.1039/c5ra19958a
https://doi.org/10.1039/c5ra19958a
Autor:
Taras Bulda, Evgeniy Y. Slobodyanyuk, Tkhe Kyong Fam, Oleksandr O. Grygorenko, Dmitry M. Volochnyuk, Oleksiy S. Artamonov
Publikováno v:
Heterocyclic Communications. 21:391-395
A stereolibrary of conformationally restricted oxazole-containing amino acids, namely all isomers of 5–pyrrolydinyl- and 5-piperidinyloxazole-4-carboxylic acids, were designed and synthesized in three steps by the reaction of the corresponding N-Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267e5e6fa56d6c975798330e0e6bf152
https://doi.org/10.1515/hc-2015-0137
https://doi.org/10.1515/hc-2015-0137
Autor:
Oleksandr O. Grygorenko, Andrii V. Bezdudny, Bohdan B. Kurpil, Sergey P. Ivonin, Dmitry M. Volochnyuk
Publikováno v:
Journal of Fluorine Chemistry. 176:78-81
An approach to the synthesis (4-di- and -trifluoroalkyl-1-alkyl-1H-pyrazol-3-yl)methylamines – promising building blocks for drug discovery and medicinal chemistry is described. The key step of the reaction sequence is fluorination of the correspon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b32e9b66ff9dec0fbe33d7297b635da
https://doi.org/10.1016/j.jfluchem.2015.06.003
https://doi.org/10.1016/j.jfluchem.2015.06.003
Publikováno v:
Heterocyclic Communications. 20:351-354
Reaction of hydrazones derived from ketones bearing an acceptor substituent adjacent to the carbonyl group (α,α,α-trifluoroacetone and ethyl pyruvate) with Vilsmeier-Haack reagent was studied. In most cases, the method allows for regioselective pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::058cd2c5189aa29d31acc7e5db411459
https://doi.org/10.1515/hc-2014-0176
https://doi.org/10.1515/hc-2014-0176
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 145:2011-2017
Reaction of hydrazones derived from active methylene compounds with the Vilsmeier–Haack reagent was studied. Compounds with sulfone, ester, nitrile, triphenylphosphonium, and phthalimide moieties were evaluated. It was found that electron-withdrawi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb21ec7ffb997961da0594b49538b4e
https://doi.org/10.1007/s00706-014-1293-7
https://doi.org/10.1007/s00706-014-1293-7
Publikováno v:
Tetrahedron Letters. 56:6248-6250
A regioselective approach to the synthesis of 2,4,5,7-tetrahydropyrrolo[3,4-c]pyrazoles, 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridines and 2,4,5,6,7,8-hexahydropyrazolo[3,4-c]azepines is described. The method relies on annulation of the saturated hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599a312836f30c1b8ec149becb5436df
https://doi.org/10.1016/j.tetlet.2015.09.108
https://doi.org/10.1016/j.tetlet.2015.09.108
Autor:
Eduard B. Rusanov, Bohdan B. Kurpil, Sergey P. Ivonin, Oleksandr O. Grygorenko, Dmitry M. Volochnyuk
Publikováno v:
Tetrahedron Letters. 55:2187-2189
Reactions of N-alkylhydrazones of aliphatic ketones with the Vilsmeier–Haack reagent (DMF–POCl3) were evaluated as a promising approach toward the synthesis of trisubstituted non-symmetric pyrazoles. It was found that either 1,3,4-trialkylpyrazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293572a7b6f529d4ed835b2115a467a3
https://doi.org/10.1016/j.tetlet.2014.02.058
https://doi.org/10.1016/j.tetlet.2014.02.058
Autor:
Andriy V. Lapandin, Sergey P. Ivonin, Dmitry A. Sibgatulin, Aleksander N. Kostyuk, Dmitry M. Volochnyuk
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 140:639-643
The reaction of push–pull enamines with 1,2-biselectrophilic phenylglyoxal was investigated. Phenylglyoxal was found to react depending on the structure of the push–pull enamine, affording either a hydroxyalkylation product at the methyl group or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61153e6bddbf50b8551ae5b2c62f104c
https://doi.org/10.1007/s00706-009-0110-1
https://doi.org/10.1007/s00706-009-0110-1