Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Dmitry M. Shayakhmetov"'
Autor:
Jia Yao, Svetlana Atasheva, Randall Toy, Emmeline L. Blanchard, Philip J. Santangelo, Krishnendu Roy, Edward S. Mocarski, Dmitry M. Shayakhmetov
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Pathogens trigger activation of sensors of the innate immune system that initiate molecular signaling enabling appropriate host defense programs. Although recognition of pathogen-specific moieties or PAMPs by specialized receptors of the imm
Externí odkaz:
https://doaj.org/article/82c6fbda93044ded80e53e06e8ddf1db
Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus
Publikováno v:
Viruses, Vol 15, Iss 6, p 1343 (2023)
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral t
Externí odkaz:
https://doaj.org/article/b04f774bf64e42caa5abcfd559a4852d
Autor:
Vasantha L. Kolachala, Sirish K. Palle, Ming Shen, Asha Shenoi, Dmitry M. Shayakhmetov, Nitika A. Gupta
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 925-942 (2019)
Current understanding is that receptor interacting serine/threonine protein kinase 1 (RIPK1) can lead to two distinct forms of cell death: RIPK3‐mediated necroptosis or caspase 8 (Casp8)‐mediated apoptosis. Here, we report that RIPK1 signaling is
Externí odkaz:
https://doaj.org/article/2da3cb6dbc564721b496494ebfded41f
Publikováno v:
Viruses, Vol 14, Iss 5, p 888 (2022)
The expression of cytokines and chemokines in response to adenovirus infection is tightly regulated by the innate immune system. Cytokine-mediated toxicity and cytokine storm are known clinical phenomena observed following naturally disseminated aden
Externí odkaz:
https://doaj.org/article/18e3be206887448c8f3941af8f445854
Autor:
Nelson C. Di Paolo, Konstantin Doronin, Lisa K. Baldwin, Thalia Papayannopoulou, Dmitry M. Shayakhmetov
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1840-1846 (2013)
Although molecular components that execute noninflammatory apoptotic cell death are well defined, molecular pathways that trigger necrotic cell death remain poorly characterized. Here, we show that in response to infection with adenovirus or Listeria
Externí odkaz:
https://doaj.org/article/5fadcdf838a349d5b535886c8f8a208c
Autor:
Dmitry M. Shayakhmetov
Publikováno v:
Viruses, Vol 2, Iss 1, Pp 244-261 (2010)
Numerous human genetic and acquired diseases could be corrected or ameliorated if viruses are harnessed to safely and effectively deliver therapeutic genes to diseased cells and tissues in vivo. Innate immune and inflammatory response represents one
Externí odkaz:
https://doaj.org/article/b6f00a6a024f4b4c950b2f21ebb40897
Autor:
Woojong Lee, Brock Kingstad-Bakke, Brett Paulson, Autumn Larsen, Katherine Overmyer, Chandranaik B Marinaik, Kelly Dulli, Randall Toy, Gabriela Vogel, Katherine P Mueller, Kelsey Tweed, Alex J Walsh, Jason Russell, Krishanu Saha, Leticia Reyes, Melissa C Skala, John-Demian Sauer, Dmitry M Shayakhmetov, Joshua Coon, Krishnendu Roy, M Suresh
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009168 (2021)
There is a critical need for adjuvants that can safely elicit potent and durable T cell-based immunity to intracellular pathogens. Here, we report that parenteral vaccination with a carbomer-based adjuvant, Adjuplex (ADJ), stimulated robust CD8 T-cel
Externí odkaz:
https://doaj.org/article/73580a7e1e6e47af817c8a1751850e37
Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus
Publikováno v:
Viruses; Volume 15; Issue 6; Pages: 1343
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral t
Publikováno v:
Molecular Therapy
Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for which we typically have little or no prior immunity, can result in epidemics with high morbidity and mortality. These epidemics can have public health and econo
Publikováno v:
Apoptosis. 26:361-370
A steatotic liver is increasingly vulnerable to ischemia reperfusion injury (IRI), and the underlying mechanisms are incompletely defined. Caspases are endo-proteases, which provide critical regulatory connections between cell death and inflammation.