Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Dmitry L. Usanov"'
Autor:
Alexander A. Peterson, Aziz M. Rangwala, Manish K. Thakur, Patrick S. Ward, Christie Hung, Ian R. Outhwaite, Alix I. Chan, Dmitry L. Usanov, Vamsi K. Mootha, Markus A. Seeliger, David R. Liu
Publikováno v:
Nature Chemical Biology. 18:1184-1195
Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel cyclophilin inhibitors from the in vitro selection of a DNA-templated
Autor:
Sonia M Vallabh, Arthur J. Campbell, Jayme L. Dahlin, Michael F. Mesleh, Kong T. Nguyen, Dominick Casalena, S. Kirk Wright, Dmitry L. Usanov, Christopher T. Lemke, Jamie A. Moroco, Joshua R. Sacher, Andrew G. Reidenbach, Murugappan Sathappa, Om K. Shrestha, Eric Vallabh Minikel, Jenna B. Yehl, Douglas S. Auld, Stuart L. Schreiber, V.L. Rangel, Alix I. Chan, Rishi N. Shah, Maria Cristina Nonato, David R. Liu, Florence F. Wagner, Alison Leed, Virendar K. Kaushik
Publikováno v:
J Biol Chem
Prion disease is a rapidly progressive neurodegenerative disorder caused by misfolding and aggregation of the prion protein (PrP), and there are currently no therapeutic options. PrP ligands could theoretically antagonize prion formation by protectin
Autor:
Alexander A, Peterson, Aziz M, Rangwala, Manish K, Thakur, Patrick S, Ward, Christie, Hung, Ian R, Outhwaite, Alix I, Chan, Dmitry L, Usanov, Vamsi K, Mootha, Markus A, Seeliger, David R, Liu
Publikováno v:
Nature chemical biology. 18(11)
Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel cyclophilin inhibitors from the in vitro selection of a DNA-templated
Publikováno v:
Organic Letters. 20:7856-7859
We developed a ruthenium-catalyzed reductive ester synthesis from aldehydes or ketones and carboxylic acids using carbon monoxide as a deoxygenative agent. Multiple factors influencing the outcome of the reaction were investigated. Best results were
Autor:
Oh Jinho, Olga Chusova, Anastasia Cherkasova, Ilia Cherkashchenko, Tatiana Petrushina, Denis Chusov, Oleg I. Afanasyev, Dmitry L. Usanov, Alexander Zarochintsev, Chun Man-Seog, Gleb L. Denisov, S. E. Semenov
Publikováno v:
European Journal of Organic Chemistry. 2019:32-35
Autor:
Vladimir B. Kharitonov, Yulia V. Nelyubina, Dmitry L. Usanov, Denis Chusov, Olga Chusova, Gleb L. Denisov, Dmitry A. Loginov, Elizaveta R. Sovdagarova, Sofiya A. Runikhina, Mikhail A. Arsenov
Publikováno v:
Journal of Organometallic Chemistry. 867:106-112
Indenyl-ligated rhodium(III) catalyst [(η5-indenyl)RhX2]n (1) is reported for the synthesis of alkylated amines via catalytic reductive amination using carbon monoxide as a reducing agent. Water as a solvent was found to be the best media for the re
Publikováno v:
Nature chemistry
DNA-encoded libraries have emerged as a widely used resource for discovery of bioactive small molecules and offer substantial advantages compared to conventional small-molecule libraries. Here we developed and streamlined multiple fundamental aspects
Publikováno v:
Organic Letters. 19:5657-5660
Rh-catalyzed one-step reductive amidation of aldehydes has been developed. The protocol does not require an external hydrogen source and employs carbon monoxide as a deoxygenative agent. The direction of the reaction can be altered simply by changing
Autor:
Alexey A. Tsygankov, Alexandra D. Samoylova, Denis Chusov, Dmitry S. Perekalin, Dmitry L. Usanov, Oleg I. Afanasyev
Publikováno v:
Synthesis. 49:2640-2651
We conducted detailed studies on CO-assisted reductive chemistry with cyclopropyl ketones as a special type of substrate. Multiple factors influencing the outcome of the reaction have been studied for both ruthenium and rhodium catalysis. An unusual
Publikováno v:
Chemical reviews. 119(23)
Reductive amination plays a paramount role in pharmaceutical and medicinal chemistry owing to its synthetic merits and the ubiquitous presence of amines among biologically active compounds. It is one of the key approaches to C-N bond construction due