Design, Synthesis, and Validation of a Novel [11C]Promethazine PET Probe for Imaging Abeta Using Autoradiography

Autor: Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham

Publikováno v: Molecules, Vol 26, Iss 8, p 2182 (2021)

Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extr

Externí odkaz: https://doaj.org/article/cfd2eccd08f44b15bb163737bf294d85

Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head.

Autor: Bou Ghanem, Ghazi O.¹ (AUTHOR) ghazi.b.ghanem@vumc.org, Koktysh, Dmitry² (AUTHOR), Baratta, Robert O.³ (AUTHOR) bob@stuarttherapeutics.com, Del Buono, Brian J.³ (AUTHOR) eric@stuarttherapeutics.com, Schlumpf, Eric³ (AUTHOR), Wareham, Lauren K.¹ (AUTHOR) lauren.wareham@vumc.org, Calkins, David J.¹ (AUTHOR) lauren.wareham@vumc.org

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Publikováno v: Nanoscale Advances; Feb2021, Vol. 3 Issue 2, p407-417, 11p

Design, Synthesis, and Validation of a Novel [ 11 C]Promethazine PET Probe for Imaging Abeta Using Autoradiography.

Autor: Whitmore, Clayton A.^1,2 (AUTHOR) clayton.whitmore@vumc.org, Boules, Mariam I.^1,2 (AUTHOR) mariam.i.boules@vumc.org, Behof, William J.^1,2 (AUTHOR) william.j.behof@vumc.org, Haynes, Justin R.^1,2 (AUTHOR) j.r.haynes@vumc.org, Koktysh, Dmitry^3,4 (AUTHOR) dmitry.koktysh@Vanderbilt.Edu, Rosenberg, Adam J.^1,2 (AUTHOR) adam.j.rosenberg@vumc.org, Tantawy, Mohammed N.^1,2 (AUTHOR) n.tantawy@vumc.org, Pham, Wellington^{1,2,4,5,6,7,8,9,10} (AUTHOR) wellington.pham@vumc.org

Publikováno v: Molecules. Apr2021, Vol. 26 Issue 8, p2182-2182. 1p.