Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dmitry Ghilarov"'
Autor:
Jeroen De Smet, Jeroen Wagemans, Maarten Boon, Pieter-Jan Ceyssens, Marleen Voet, Jean-Paul Noben, Julia Andreeva, Dmitry Ghilarov, Konstantin Severinov, Rob Lavigne
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109567- (2021)
Summary: The bacterial DNA gyrase complex (GyrA/GyrB) plays a crucial role during DNA replication and serves as a target for multiple antibiotics, including the fluoroquinolones. Despite it being a valuable antibiotics target, resistance emergence by
Externí odkaz:
https://doaj.org/article/daf11f2b61e945c7b8398e6544f55c20
Autor:
Elizabeth Michalczyk, Kay Hommernick, Iraj Behroz, Marcel Kulike, Zuzanna Pakosz-Stępień, Lukasz Mazurek, Maria Seidel, Maria Kunert, Karine Santos, Holger von Moeller, Bernhard Loll, John B. Weston, Andi Mainz, Jonathan G. Heddle, Roderich D. Süssmuth, Dmitry Ghilarov
Publikováno v:
Nature Catalysis. 6:52-67
The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However, its mode of action is poorly understood. We determined a 2.6 Å resolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f6167c88a9b76782c22e90ef4bd332
https://doi.org/10.1038/s41929-022-00904-1
https://doi.org/10.1038/s41929-022-00904-1
Autor:
Mareike Saathoff, Simone Kosol, Torsten Semmler, Karsten Tedin, Nicole Dimos, Johannes Kupke, Maria Seidel, Fereshteh Ghazisaeedi, Silver A. Wolf, Benno Kuropka, Wojciech Czyszczoń, Dmitry Ghilarov, Stefan Grätz, Jonathan G. Heddle, Bernhard Loll, Roderich D. Süssmuth, Marcus Fulde
Antibiotic resistance is a continuously increasing concern for public health care. Understanding resistance mechanisms and their emergence is crucial for the development of new antibiotics and their effective use. Here, we report the discovery of a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2185ac87b00e7765241874322906d042
https://doi.org/10.1101/2022.09.15.507240
https://doi.org/10.1101/2022.09.15.507240
Autor:
Roderich D. Süssmuth, Dmitry Ghilarov, Elizabeth Michalczyk, Zuzanna Pakosz, Jonathan G. Heddle, Łukasz Mazurek, Wojciech Czyszczon, Karolina Wawro, Mikhail Metelev, Iraj Behroz, Svetlana Dubiley
Publikováno v:
Nucleic Acids Research
DNA gyrase, a type II topoisomerase found predominantly in bacteria, is the target for a variety of ‘poisons’, namely natural product toxins (e.g. albicidin, microcin B17) and clinically important synthetic molecules (e.g. fluoroquinolones). Resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1d1cea77ed1952c0aae74d0bd03269
https://doi.org/10.1093/nar/gkaa1266
https://doi.org/10.1093/nar/gkaa1266
Autor:
Elizabeth Michalczyk, Konstantinos Beis, Graham C. Walker, Sylvie Rebuffat, Feng Qu, Dmitry Ghilarov, Zuzanna Pakosz, Piotr Stepien, Satoshi Ogasawara, Norimichi Nomura, Jonathan G. Heddle, So Iwata, Satomi Inaba-Inoue
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (37), ⟨10.1126/sciadv.abj5363⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (37), ⟨10.1126/sciadv.abj5363⟩
Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of enteric bacteria to multiple peptide antibiotics is controlled by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a8fd9670caa4593c8dc93091ee3d88
https://pubmed.ncbi.nlm.nih.gov/34516884
https://pubmed.ncbi.nlm.nih.gov/34516884
Autor:
Wojciech Czyszczon, Jonathan G. Heddle, Zuzanna Pakosz, Karolina Wawro, Roderich D. Suessmuth, Iraj Behroz, Lukasz Mazurek, Dmitry Ghilarov, Elizabeth Michalczyk
DNA gyrase, a type II topoisomerase found predominantly in bacteria, is the target for a variety of “poisons”, namely natural product toxins (e.g. albicidin. microcin B17) and clinically important synthetic molecules (e.g. fluoroquinolones). Resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faf3673820437b073b352aae6e8964cd
https://doi.org/10.1101/2020.09.24.310243
https://doi.org/10.1101/2020.09.24.310243
Autor:
Dmitry Ghilarov, Anthony Maxwell, Konstantin Severinov, Dmitrii Y. Travin, Marina V. Serebryakova, Julia Piskunova, Clare E. M. Stevenson, David M. Lawson
Publikováno v:
Molecular Cell
Summary The introduction of azole heterocycles into a peptide backbone is the principal step in the biosynthesis of numerous compounds with therapeutic potential. One of them is microcin B17, a bacterial topoisomerase inhibitor whose activity depends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118eef6842d1980e1624406f21d95875
https://pubmed.ncbi.nlm.nih.gov/30661981
https://pubmed.ncbi.nlm.nih.gov/30661981
Autor:
Dmitry Ghilarov, Mikhail Metelev, Ekaterina S. Komarova, Ilya A. Osterman, Dmitrii Y. Travin, Konstantin Severinov, Marina V. Serebryakova
Klebsazolicin (KLB) is a recently discovered Klebsiella pneumonia peptide antibiotic targeting the exit tunnel of bacterial ribosome. KLB contains an N-terminal amidine ring and four azole heterocycles installed into a ribosomally synthesized precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29ec9fbcfc67bddfb619139f616f448
https://ruj.uj.edu.pl/xmlui/handle/item/279783
https://ruj.uj.edu.pl/xmlui/handle/item/279783
Autor:
Alexander Yakimov, T. O. Artamonova, Konstantin Severinov, Andrey L. Konevega, Konstantin A. Shabalin, Yury S. Polikanov, Irina Utkina, Dmitry Y Travin, Petr V. Sergiev, Dmitry Ghilarov, Marina V. Serebryakova, Ekaterina S. Komarova, Mikhail Khodorkovskii, Nelli F Khabibullina, Ilya A. Osterman, Mikhail Metelev
Publikováno v:
Nature chemical biology
Whereas screening of the small-molecule metabolites produced by most cultivatable microorganisms often results in the rediscovery of known compounds, genome-mining programs allow researchers to harness much greater chemical diversity, and result in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5981464f96fb0db8d70d3b3d8b750b4
https://ruj.uj.edu.pl/xmlui/handle/item/279785
https://ruj.uj.edu.pl/xmlui/handle/item/279785
Autor:
Mikhail Metelev, Dmitry Ghilarov
Publikováno v:
Molecular Biology. 48:29-45
A great variety of prokaryotic ribosomally synthesized and posttranslationally modified peptides (RiPPs) were predicted and identified experimentally owing to recent advances in large-scale genome sequencing and data analysis. Thiazole/oxazole-modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f402c88a0c7f090d688992a81a2f9639
https://doi.org/10.1134/s0026893314010105
https://doi.org/10.1134/s0026893314010105