Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Dmitry B. Veprintsev"'
Autor:
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J. Koers, Qingchao Chen, Patricia C. Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B. Veprintsev, Nagarajan Vaidehi, Simone N. Weyand, Christopher G. Tate
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar
Externí odkaz:
https://doaj.org/article/652fff5f256d4ddc952071804619e0c2
Autor:
Sean A. Cullum, Simon Platt, Natasha Dale, Oliver C. Isaac, Edward S. Wragg, Mark Soave, Dmitry B. Veprintsev, Jeanette Woolard, Laura E. Kilpatrick, Stephen J. Hill
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The concept of agonist-independent signalling that can be attenuated by inverse agonists is a fundamental element of the cubic ternary complex model of G protein-coupled receptor (GPCR) activation. This model shows how a GPCR can exist in tw
Externí odkaz:
https://doaj.org/article/1c67926d1da64115a6683f7383bac865
Autor:
Miroslav Kosar, Roman C. Sarott, David A. Sykes, Alexander E. G. Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L. Z. Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J. Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J. McCormick, Tian Hua, Christian W. Gruber, Dmitry B. Veprintsev, James A. Frank, Uwe Grether, Erick M. Carreira
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 956-968 (2024)
Externí odkaz:
https://doaj.org/article/a9641dd9dece4c6580e5b5242c4407b7
Autor:
Morgan Scott-Dennis, Fikri A. Rafani, Yicheng Yi, Themiya Perera, Clare R. Harwood, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Dmitry B. Veprintsev, David A. Sykes
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The cannabinoid receptor (CBR) subtypes 1 (CB1R) and 2 (CB2R) are key components of the endocannabinoid system (ECS), playing a central role in the control of peripheral pain, inflammation and the immune response, with further roles in
Externí odkaz:
https://doaj.org/article/bd3b602001cb48838825a2f74ab966f7
Autor:
Mireia Jiménez‐Rosés, Bradley Angus Morgan, Maria Jimenez Sigstad, Thuy Duong Zoe Tran, Rohini Srivastava, Asuman Bunsuz, Leire Borrega‐Román, Pattarin Hompluem, Sean A. Cullum, Clare R. Harwood, Eline J. Koers, David A. Sykes, Iain B. Styles, Dmitry B. Veprintsev
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract G protein‐coupled receptors (GPCRs) are valuable therapeutic targets for many diseases. A central question of GPCR drug discovery is to understand what determines the agonism or antagonism of ligands that bind them. Ligands exert their act
Externí odkaz:
https://doaj.org/article/8c395ffb80f645bb9233171b8236b0df
Autor:
David A. Sykes, Mireia Jiménez‐Rosés, John Reilly, Robin A. Fairhurst, Steven J. Charlton, Dmitry B. Veprintsev
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract In this study, we report the β1‐adrenoceptor binding kinetics of several clinically relevant β1/2‐adrenoceptor (β1/2AR) agonists and antagonists. [3H]‐DHA was used to label CHO‐β1AR for binding studies. The kinetics of ligand bin
Externí odkaz:
https://doaj.org/article/23a0dbaf85364a89ad9273ace3affdf9
Autor:
Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C
Externí odkaz:
https://doaj.org/article/3fb017c511b74ac5b642a4f342d8976b
Autor:
Franziska M. Heydenreich, Tamara Miljuš, Rolf Jaussi, Roger Benoit, Dalibor Milić, Dmitry B. Veprintsev
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Site-directed scanning mutagenesis is a powerful protein engineering technique which allows studies of protein functionality at single amino acid resolution and design of stabilized proteins for structural and biophysical work. However, crea
Externí odkaz:
https://doaj.org/article/1b11ce312b1949debc1d11e568ec22af
Autor:
Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, w
Externí odkaz:
https://doaj.org/article/6eba6ba8e03a459fb317fb0b5ab08460
Autor:
Philip Rößler, Daniel Mayer, Ching-Ju Tsai, Dmitry B. Veprintsev, Gebhard F. X. Schertler, Alvar D. Gossert
Publikováno v:
Molecules, Vol 25, Iss 24, p 5984 (2020)
In this work, we examine methyl nuclear magnetic resonance (NMR) spectra of the methionine ε-[13CH3] labelled thermostabilized β1 adrenergic receptor from turkey in association with a variety of different effectors, including mini-Gs and nanobody 6
Externí odkaz:
https://doaj.org/article/96d2b623dd234e1ba8de5ea56ecfc1d0