Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dmitry A. Suplatov"'
Probing the role of the residues in the active site of the transaminase from Thermobaculum terrenum.
Autor:
Ekaterina Yu Bezsudnova, Alena Yu Nikolaeva, Alina K Bakunova, Tatiana V Rakitina, Dmitry A Suplatov, Vladimir O Popov, Konstantin M Boyko
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255098 (2021)
Creating biocatalysts for (R)-selective amination effectively is highly desirable in organic synthesis. Despite noticeable progress in the engineering of (R)-amine activity in pyridoxal-5'-phosphate-dependent transaminases of fold type IV, the specia
Externí odkaz:
https://doaj.org/article/8d9e7e54227c47c895f595f8bffbc68c
Publikováno v:
Bioinformatics. 38:985-989
Motivation With the increasing availability of 3D-data, the focus of comparative bioinformatic analysis is shifting from protein sequence alignments toward more content-rich 3D-alignments. This raises the need for new ways to improve the accuracy of
Autor:
Vladimir V. Voevodin, Ivan Timokhin, Yana A. Sharapova, Dmitry A. Suplatov, Nina Popova, Maksim V. Shegay, Vytas K. Švedas
Publikováno v:
The Journal of Supercomputing. 77:12382-12398
The field of biology is producing data faster than ever before. To approach its analysis efficiently, one can take advantage of a systematic symbiosis between the power of huge distributed-memory systems and the flexibility of locally managed shared-
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1302-1311 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Local 3D-structural differences in homologous proteins contribute to functional diversity observed in a superfamily, but so far received little attention as bioinformatic analysis was usually carried out at the level of amino
Local 3D-structural differences in homologous proteins contribute to functional diversity observed in a superfamily, but so far received little attention as bioinformatic analysis was usually carried out at the level of amino
Publikováno v:
Journal of Chemical Information and Modeling. 60:3692-3696
The ability of ligands to form crucial interactions with a protein target, characteristic for the substrate and/or inhibitors, could be considered a structural criterion for identifying potent binders among docked compounds. Structural filtration of
Publikováno v:
Nucleic Acids Research
Zebra2 is a highly automated web-tool to search for subfamily-specific and conserved positions (i.e. the determinants of functional diversity as well as the key catalytic and structural residues) in protein superfamilies. The bioinformatic analysis i
Yosshi: a web-server for disulfide engineering by bioinformatic analysis of diverse protein families
Publikováno v:
Nucleic Acids Research
Disulfide bonds play a significant role in protein stability, function or regulation but are poorly conserved among evolutionarily related proteins. The Yosshi can help to understand the role of S–S bonds by comparing sequences and structures of ho
Autor:
Ekaterina Yu. Bezsudnova, Konstantin M. Boyko, Alena Yu. Nikolaeva, Yulia S. Zeifman, Tatiana V. Rakitina, Dmitry A. Suplatov, Vladimir O. Popov
Publikováno v:
Biochimie. 158:130-138
The high catalytic efficiency of enzymes under reaction conditions is one of the main goals in biocatalysis. Despite the dramatic progress in the development of more efficient biocatalysts by protein design, the search for natural enzymes with useful
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:2049-2060
Doramapimod (BIRB-796) is widely recognized as one of the most potent and selective type II inhibitors of human p38α mitogen-activated protein kinase (MAPK); however, the understanding of its binding mechanism remains incomplete. Previous studies in
Autor:
Garri Manasaryan, D. K. Nilov, Vytas K. Švedas, Sergey Pushkarev, A. N. Kuimov, Dmitry A. Suplatov, Viktor Drobot
Publikováno v:
Cancers, Vol 13, Iss 1201, p 1201 (2021)
Cancers
Volume 13
Issue 6
Cancers
Volume 13
Issue 6
Simple Summary The PARP family consists of 17 proteins, and some of them are responsible for cancer cells’ viability. Much attention is therefore given to the search for chemical compounds with the ability to suppress distinct PARP family members (