Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dmitry A. Khlevin"'
Synthesis and cytotoxicity of novel simplified eleutherobin analogues as potential antitumour agents
Autor:
Yulia A. Gracheva, Vladimir A. Palyulin, Marina N. Semenova, Dmitry I. Osolodkin, Victor V. Semenov, Marina V. Proskurnina, Anastasia V Tutushkina, Alexander A. Shtil, Nikolay S. Zefirov, Valeria A. Glazunova, S. E. Sosonyuk, Dmitry A. Khlevin, N. A. Lozinskaya, Anita Peshich
Publikováno v:
Organicbiomolecular chemistry. 17(10)
Mixed simplified structures containing the paclitaxel and eleutherobin pharmacophore moieties were analyzed using molecular docking techniques and synthesized based on adamantane and 8-oxabicyclo[3.2.1]octane scaffolds. The crucial role of substituen
Publikováno v:
European Journal of Organic Chemistry. 2013:2381-2388
The first directed synthesis of seven-membered mono- and tris-phosphates is described. The key steps involve a DIBAL-H/DIBAL-Cl-mediated ring opening of 8-oxabicyclo[3.2.1]octenes in the presence of [Ni(acac)2] and stereoselective syn-dihydroxylation
Publikováno v:
Tetrahedron. 68:5785-5792
The synthesis of new polyhydroxylated 8-oxabicyclo[3.2.1]octanes and 2,7-dioxatricyclo[4.2.1.03,8]nonanes is described. These structures is an interesting synthetic blocks for potential bioactive molecules. The precursor, 3-chloro-8-oxabicyclo[3.2.1]