Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dmitry A. Bosykh"'
Autor:
Pavel G. Komarov, Ivanda Pavlovska, Swati Sathe, Elena A. Komarova, Lyudmila G. Burdelya, Evguenia Strom, Olga B. Chernova, Roger M. Macklis, Rami Skaliter, Inna Shyshynova, Dmitry A. Bosykh, Andrei V. Gudkov
Publikováno v:
Nature Chemical Biology. 2:474-479
p53-dependent apoptosis contributes to the side effects of cancer treatment, and genetic or pharmacological inhibition of p53 function can increase normal tissue resistance to genotoxic stress. It has recently been shown that p53 can induce apoptosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd368faf7f8117ea2497a0e0e714e1d9
https://doi.org/10.1038/nchembio809
https://doi.org/10.1038/nchembio809
Curaxins: Anticancer Compounds That Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT
Autor:
Jean Veith, Mairead Commane, Anton A. Komar, Igor Koman, Dmitry A. Bosykh, Srabani Pal, Catherine Burkhart, Mahadeb Pal, Katerina Gurova, Leonid Brodsky, Andrei V. Gudkov, Alexander V. Gasparian, Alfiya Safina, Sergey Sviridov, Madhi Saranadasa, Andrei Purmal, Olga A. Guryanova
Publikováno v:
Science Translational Medicine. 3
Effective eradication of cancer requires treatment directed against multiple targets. The p53 and nuclear factor κB (NF-κB) pathways are dysregulated in nearly all tumors, making them attractive targets for therapeutic activation and inhibition, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1065ca630da14d42a464cd2582be883e
https://doi.org/10.1126/scitranslmed.3002530
https://doi.org/10.1126/scitranslmed.3002530
Autor:
Tom R. Webb, Anatoly Prokvolit, Eugenia Samoylova, Andrei V. Gudkov, Natalia D. Tararova, Dmitriy Lvovskiy, Mahrukh K. Ganapathi, Canhui Guo, Dmitry A. Bosykh, Lyudmila G. Burdelya, Ram Ganapathi, Katerina Gurova, Anna V. Khodyakova, George R. Stark, Jason E. Hill
Renal cell carcinomas (RCC) commonly retain wild-type but functionally inactive p53, which is repressed by an unknown dominant mechanism. To help reveal this mechanism, we screened a diverse chemical library for small molecules capable of restoring p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0b1ccbf5e4b3ed6dfcbdfa07da50ef
https://europepmc.org/articles/PMC1297696/
https://europepmc.org/articles/PMC1297696/
