Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Dmitry A Ovchinnikov"'
Autor:
Petr O Ilyinskii, Grigoriy I Kovalev, Conlin P O'Neil, Christopher J Roy, Alicia M Michaud, Natalia M Drefs, Mikhail A Pechenkin, Fen-Ni Fu, Lloyd P M Johnston, Dmitry A Ovchinnikov, Takashi Kei Kishimoto
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197694 (2018)
We previously reported that synthetic vaccine particles (SVP) encapsulating antigens and TLR agonists resulted in augmentation of immune responses with minimal production of systemic inflammatory cytokines. Here we evaluated two different polymer for
Externí odkaz:
https://doaj.org/article/9f01f61eeda54a439de2914fa8f41d1c
Autor:
Stephanie F Bellmaine, Dmitry A Ovchinnikov, David T Manallack, Claire E Cuddy, Andrew G Elefanty, Edouard G Stanley, Ernst J Wolvetang, Spencer J Williams, Martin Pera
Publikováno v:
eLife, Vol 6 (2017)
Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cel
Externí odkaz:
https://doaj.org/article/64708b8f9f454c8ea234db5e3b8859a8
Autor:
Yu Hasegawa, Deanne Taylor, Dmitry A Ovchinnikov, Ernst J Wolvetang, Laurence de Torrenté, Jessica C Mar
Publikováno v:
PLoS Genetics, Vol 11, Iss 8, p e1005428 (2015)
An analysis of gene expression variability can provide an insightful window into how regulatory control is distributed across the transcriptome. In a single cell analysis, the inter-cellular variability of gene expression measures the consistency of
Externí odkaz:
https://doaj.org/article/eca6fa4ec3744d938ac95f297779e59f
Autor:
Desi Veleva, Merve Ay, Dmitry A. Ovchinnikov, Andrew B.J. Prowse, Minal J. Menezes, Michael Nafisinia
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103407- (2024)
We employed a Sendai virus-based reprogramming method to transform human lymphoblastoid cell lines (LCL) derived from two individuals diagnosed with phenylketonuria (PKU) into induced pluripotent stem cells (iPSC). This reprogramming process involved
Externí odkaz:
https://doaj.org/article/eb9b212926cf4db8ad4b0872f9a31338
Autor:
Desi Veleva, Merve Ay, Dmitry A. Ovchinnikov, Andrew B.J. Prowse, Minal J. Menezes, Michael Nafisinia
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103405- (2024)
Phenylketonuria is a rare autosomal recessive metabolic disorder mainly due to a significant reduction in the enzyme phenylalanine hydroxylase, resulting in elevation of phenylalanine in the blood. Here, we have established two fibroblast-derived ind
Externí odkaz:
https://doaj.org/article/ce4f8dc0398c4699a2df95af4f46e35a
Autor:
Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40742 (2012)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
Externí odkaz:
https://doaj.org/article/d5eaa5f72a81446caa82d85295dc8909
Autor:
Wendy J van Zuylen, Valerie Garceau, Adi Idris, Kate Schroder, Katharine M Irvine, Jane E Lattin, Dmitry A Ovchinnikov, Andrew C Perkins, Andrew D Cook, John A Hamilton, Paul J Hertzog, Katryn J Stacey, Stuart Kellie, David A Hume, Matthew J Sweet
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15723 (2011)
BackgroundThe ten mouse and six human members of the Schlafen (Slfn) gene family all contain an AAA domain. Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation
Externí odkaz:
https://doaj.org/article/0e772b52cc8148969f6d70d48c2a29ad
Autor:
Dmitry A. Ovchinnikov, Sharon Jong, Claire Cuddy, Kelly Dalby, Orrin Devinsky, Saul Mullen, Snezana Maljevic, Steve Petrou
Publikováno v:
Stem Cell Research, Vol 76, Iss , Pp 103367- (2024)
Many developmental and epileptic encephalopathies (DEEs) result from variants in cation channel genes. Using mRNA transfection, we generated and characterised an induced pluripotent stem cell (iPSC) line from the fibroblasts of a male late-onset DEE
Externí odkaz:
https://doaj.org/article/ae358e4384da49808c1b9d0ed4b4204c
Autor:
Timothy J. Tracey, Leanne Jiang, Melinder K. Gill, Samara N. Ranie, Dmitry A. Ovchinnikov, Ernst J. Wolvetang, Shyuan T. Ngo
Publikováno v:
Stem Cell Research, Vol 70, Iss , Pp 103137- (2023)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which the TDP-43 protein is believed to play a central role in disease pathophysiology. Using the CRISPR-Cas9 system, we introduced the heterozygous c.1144G > A (p.A382
Externí odkaz:
https://doaj.org/article/a5ce9f3de3f9419a991dc0ff9cf459af
Autor:
Dmitry A. Ovchinnikov
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102103- (2020)
Stem Cell Research is pleased to introduce into its publication portfolio a new article type: a template-driven short report on the generation of a novel Genetically Modified Cell Line. This resource type is typically derived from human pluripotent s
Externí odkaz:
https://doaj.org/article/d2035f6071e4445c8aeb83b043850a7c