Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Dmitry, Guschin"'
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3
https://doi.org/10.1038/s41591-019-0478-3
Autor:
Daria Bulanova, Aleksandr Ianevski, Andrii Bugai, Yevhen Akimov, Suvi Kuivanen, Henrik Paavilainen, Laura Kakkola, Jatin Nandania, Laura Turunen, Tiina Ohman, Hanna Ala-Hongisto, Hanna M. Pesonen, Marika S. Kuisma, Anni Honkimaa, Emma L. Walton, Valentyn Oksenych, Martina B. Lorey, Dmitry Guschin, Jungmin Shim, Jinhee Kim, Thoa T. Than, So Young Chang, Veijo Hukkanen, Evgeny Kulesskiy, Varpu S. Marjomaki, Ilkka Julkunen, Tuula A. Nyman, Sampsa Matikainen, Jani S. Saarela, Famara Sane, Didier Hober, Gülsah Gabriel, Jef K. De Brabander, Miika Martikainen, Marc P. Windisch, Ji-Young Min, Roberto Bruzzone, Tero Aittokallio, Markus Vähä-Koskela, Olli Vapalahti, Arto Pulk, Vidya Velagapudi, Denis E. Kainov
Publikováno v:
Viruses, Vol 9, Iss 10, p 271 (2017)
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-ap
Externí odkaz:
https://doaj.org/article/a2efcfb6a1b5438e8d4582f4bed8125b
Autor:
Alexander Kagansky, Svetlana Zvereva, Julian M. Rozenberg, Lamak Alsoulaiman, Stanislav Rybtsov, Dmitry Guschin
Publikováno v:
Experimental Hematology. 88:S78
The origin of glial macrophages and their role in pathology is debated (Gutmann and Kettenmann 2019). In gliomas, paired TP53/IDH1 mutations are associated with lower immune infiltration and better outcomes (Cancer Genome Atlas Research Network et al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e095cb20bddeaf9bbc6045c509cf1a
https://doi.org/10.1016/j.exphem.2020.09.138
https://doi.org/10.1016/j.exphem.2020.09.138
Autor:
Joal D. Beane, David Paschon, Richard A. Morgan, Mary A. Black, Martin A. Giedlin, Andreas Reik, Philip D. Gregory, Zhili Zheng, Jeffrey C. Miller, Gary Lee, Daniel Abate-Daga, Michael C. Holmes, Matthew C. Mendel, Edward J. Rebar, Dmitry Guschin, Zhiya Yu, Smita S. Chandran, Mini Bharathan, Steven A. Feldman, Nicholas P. Restifo, Nimisha Gandhi, Dale Ando, Steven A. Rosenberg
Publikováno v:
Molecular Therapy. 23:1380-1390
Programmed cell death-1 (PD-1) is expressed on activated T cells and represents an attractive target for gene-editing of tumor targeted T cells prior to adoptive cell transfer (ACT). We used zinc finger nucleases (ZFNs) directed against the gene enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693fa05bd8b9498036b2d7a660d38336
https://doi.org/10.1038/mt.2015.71
https://doi.org/10.1038/mt.2015.71
Autor:
Bryan, Zeitler, Steven, Froelich, Kimberly, Marlen, David A, Shivak, Qi, Yu, Davis, Li, Jocelynn R, Pearl, Jeffrey C, Miller, Lei, Zhang, David E, Paschon, Sarah J, Hinkley, Irina, Ankoudinova, Stephen, Lam, Dmitry, Guschin, Lexi, Kopan, Jennifer M, Cherone, Hoang-Oanh B, Nguyen, Guijuan, Qiao, Yasaman, Ataei, Matthew C, Mendel, Rainier, Amora, Richard, Surosky, Josee, Laganiere, B Joseph, Vu, Anand, Narayanan, Yalda, Sedaghat, Karsten, Tillack, Christina, Thiede, Annette, Gärtner, Seung, Kwak, Jonathan, Bard, Ladislav, Mrzljak, Larry, Park, Taneli, Heikkinen, Kimmo K, Lehtimäki, Marie M, Svedberg, Jenny, Häggkvist, Lenke, Tari, Miklós, Tóth, Andrea, Varrone, Christer, Halldin, Andrea E, Kudwa, Sylvie, Ramboz, Michelle, Day, Jyothisri, Kondapalli, D James, Surmeier, Fyodor D, Urnov, Philip D, Gregory, Edward J, Rebar, Ignacio, Muñoz-Sanjuán, H Steve, Zhang
Publikováno v:
Nature medicine. 25(7)
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d3620bad8fe21aa64bd37ef53578561
https://pubmed.ncbi.nlm.nih.gov/31263285
https://pubmed.ncbi.nlm.nih.gov/31263285
Autor:
H Steve, Zhang, Dingang, Liu, Yan, Huang, Stefan, Schmidt, Reed, Hickey, Dmitry, Guschin, Haili, Su, Ion S, Jovin, Mike, Kunis, Sarah, Hinkley, Yuxin, Liang, Linda, Hinh, S Kaye, Spratt, Casey C, Case, Edward J, Rebar, Barbara E, Ehrlich, Barbara, Ehrlich, Philip D, Gregory, Frank J, Giordano
Publikováno v:
Molecular Therapy
Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists is often hampered by targets that are not druggable using conventional approaches. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6d75f77ecc7bd1ea7a45b7b9474c4
http://europepmc.org/articles/PMC3412484
http://europepmc.org/articles/PMC3412484
Autor:
Philip D. Gregory, Edward J. Rebar, Dirk Hockemeyer, Lauren K. Fong, Xiangdong Meng, Lei Zhang, Vikram Khurana, Richard H. Myers, B. Joseph Vu, Susan Lindquist, Qing Gao, Lawrence I. Golbe, Rudolf Jaenisch, H. Steve Zhang, Fyodor D. Urnov, Frank Soldner, Albert W. Cheng, Josee Laganiere, Dmitry Guschin, Raaji Alagappan
Publikováno v:
Cell. 146:318-331
Summary Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitation has been the inabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28903e051b95b7215ea5ebd0fb54f544
https://doi.org/10.1016/j.cell.2011.06.019
https://doi.org/10.1016/j.cell.2011.06.019
Autor:
Krystof S. Bankiewicz, Louisa C Johnston, Xiaomin Su, Karen Horovitz, Piotr Hadaczek, Howard J. Federoff, John Forsayeth, Dmitry Guschin, Irina Ankoudinova, Kathleen A. Maguire-Zeiss
Publikováno v:
Molecular Therapy. 16(8):1392-1399
In Parkinson's disease (PD) chronic inflammation occurs in the substantia nigra (SNc) concurrently with dopaminergic neurodegeneration. In models of PD, microglial activation precedes neurodegeneration in the SNc, suggesting that the underlying patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70d569b6305188f7508a5c0c24f63b9
Autor:
Jianbin Wang, Christian Beauséjour, Philip D. Gregory, Kenneth Kim, Carl O. Pabo, Jeffrey C. Miller, Adam James Waite, Dmitry Guschin, Nathaniel Wang, Igor Rupniewski, Edward J. Rebar, Ya-Li Lee, Michael C. Holmes
Publikováno v:
Nature Biotechnology. 25:778-785
Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification efficiencies (>10%) by introducing a recombinogenic double-strand break into the targeted gene. The cleavage event is induced using two custom-designed ZFNs that hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571e5e12f3a045008a9966d66abe0515
https://doi.org/10.1038/nbt1319
https://doi.org/10.1038/nbt1319
Autor:
Luigi Naldini, Dmitry Guschin, Anthony Conway, Gregory J. Cost, Pietro Genovese, Philip D. Gregory, Angelo Lombardo, Michael C. Holmes
Publikováno v:
Molecular Therapy. 23
Mutations in the IL2RG gene may result in X-linked severe combined immunodeficiency (X-SCID), an immunodeficiency disorder in which the body produces very few T cells and natural killer cells, resulting in premature death due to opportunistic infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164134582852f1ea9a6f6bf2c1623d06