Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Dmitriy M Chudakov"'
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism
Autor:
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov
Publikováno v:
eLife, Vol 12 (2024)
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II. However, it remains largely unknown whether distinct or shared reper
Externí odkaz:
https://doaj.org/article/62a2acd1ab584584af575e33ae102adc
Autor:
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys
Publikováno v:
eLife, Vol 12 (2023)
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,
Externí odkaz:
https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc
Autor:
Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov
Publikováno v:
eLife, Vol 12 (2023)
High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade.
Externí odkaz:
https://doaj.org/article/c87c8bb98b6f453b939d96cb7813cfcf
Autor:
Artem Mikelov, Evgeniia I Alekseeva, Ekaterina A Komech, Dmitry B Staroverov, Maria A Turchaninova, Mikhail Shugay, Dmitriy M Chudakov, Georgii A Bazykin, Ivan V Zvyagin
Publikováno v:
eLife, Vol 11 (2022)
The stability and plasticity of B cell-mediated immune memory ensures the ability to respond to the repeated challenges. We have analyzed the longitudinal dynamics of immunoglobulin heavy chain repertoires from memory B cells, plasmablasts, and plasm
Externí odkaz:
https://doaj.org/article/abfef42b83a945a8a9be7f4644f92e8d
Autor:
Mikhail M Goncharov, Ekaterina A Bryushkova, Nikita I Sharaev, Valeria D Skatova, Anastasiya M Baryshnikova, George V Sharonov, Vadim Karnaukhov, Maria T Vakhitova, Igor V Samoylenko, Lev V Demidov, Sergey Lukyanov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya
Publikováno v:
eLife, Vol 11 (2022)
Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantig
Externí odkaz:
https://doaj.org/article/30db95cf742145ff8d7397b243775448
Autor:
Anastasia A Minervina, Ekaterina A Komech, Aleksei Titov, Meriem Bensouda Koraichi, Elisa Rosati, Ilgar Z Mamedov, Andre Franke, Grigory A Efimov, Dmitriy M Chudakov, Thierry Mora, Aleksandra M Walczak, Yuri B Lebedev, Mikhail V Pogorelyy
Publikováno v:
eLife, Vol 10 (2021)
COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. T cells play a key role in the adaptive antiviral immune response by killing infected cells and facilitating the selection of virus-specific antibodies. However, neither the dynamics
Externí odkaz:
https://doaj.org/article/e8a8849ef3cd4959a18664b9fff35eb4
Autor:
Sofya A Kasatskaya, Kristin Ladell, Evgeniy S Egorov, Kelly L Miners, Alexey N Davydov, Maria Metsger, Dmitry B Staroverov, Elena K Matveyshina, Irina A Shagina, Ilgar Z Mamedov, Mark Izraelson, Pavel V Shelyakin, Olga V Britanova, David A Price, Dmitriy M Chudakov
Publikováno v:
eLife, Vol 9 (2020)
The organizational integrity of the adaptive immune system is determined by functionally discrete subsets of CD4+ T cells, but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed T-cell receptors (TCRs). To
Externí odkaz:
https://doaj.org/article/1dd049e96e1b4c82816146e92ae81118
Autor:
Anastasia A Minervina, Mikhail V Pogorelyy, Ekaterina A Komech, Vadim K Karnaukhov, Petra Bacher, Elisa Rosati, Andre Franke, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak
Publikováno v:
eLife, Vol 9 (2020)
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Using TCR alpha and beta repertoire sequencing for T-cell subsets, as well as single-cell RNAseq and TCRseq, we track the concentrations
Externí odkaz:
https://doaj.org/article/be440afc27fe45aeb9cbe3fd0dd9c7d1
Autor:
Mikhail V Pogorelyy, Anastasia A Minervina, Mikhail Shugay, Dmitriy M Chudakov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak
Publikováno v:
PLoS Biology, Vol 17, Iss 6, p e3000314 (2019)
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant information from large high-throughput sequencing of TCR repertoires (Re
Externí odkaz:
https://doaj.org/article/f13a9335fc074698b5d77df7658e6bb9
Autor:
Mikhail V Pogorelyy, Anastasia A Minervina, Dmitriy M Chudakov, Ilgar Z Mamedov, Yuri B Lebedev, Thierry Mora, Aleksandra M Walczak
Publikováno v:
eLife, Vol 7 (2018)
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide diseas
Externí odkaz:
https://doaj.org/article/7fa7e2d8bd5145f898313beacb2dd9b1