Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Dmitriy M, Chudakov"'
Autor:
Anastasiia Tsareva, Pavel V. Shelyakin, Irina A. Shagina, Mikhail Yu. Myshkin, Ekaterina M. Merzlyak, Valeriia V. Kriukova, Alexander S. Apt, Irina A. Linge, Dmitriy M. Chudakov, Olga V. Britanova
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium tuberculosis (Mtb) remains a major threat worldwide, although only a fraction of infected individuals develops tuberculosis (TB). TB susceptibility is shaped by multiple genetic factors, and we performed comparative immunological analys
Externí odkaz:
https://doaj.org/article/21bbd6e3c48540329f6d1feed125b949
Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism
Autor:
Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov
Publikováno v:
eLife, Vol 12 (2024)
Suppressive function of regulatory T cells (Treg) is dependent on signaling of their antigen receptors triggered by cognate self, dietary, or microbial peptides presented on MHC II. However, it remains largely unknown whether distinct or shared reper
Externí odkaz:
https://doaj.org/article/62a2acd1ab584584af575e33ae102adc
Autor:
Maria O. Ustiuzhanina, Maria A. Streltsova, Nikita D. Timofeev, Maxim A. Kryukov, Dmitriy M. Chudakov, Elena I. Kovalenko
Publikováno v:
Cells, Vol 13, Iss 6, p 530 (2024)
NK cells play a decisive role in controlling hCMV infection by combining innate and adaptive-like immune reactions. The hCMV-derived VMAPRTLFL (LFL) peptide is a potent activator of NKG2C+ NK cells. Proposed here is an autologous system of LFL stimul
Externí odkaz:
https://doaj.org/article/77ff7f1944194e9f9441f9447796d994
Autor:
Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Alexander Y. Komkov
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T-cell receptor (TR) diversity of the variable domains is generated by recombination of both the alpha (TRA) and beta (TRB) chains. The textbook process of TRB chain production starts with TRBD and TRBJ gene rearrangement, followed by the rearrangeme
Externí odkaz:
https://doaj.org/article/7c744d23d4c24f8fa70e56c8a7bd5e3e
Autor:
Oksana V. Stanevich, Evgeniia I. Alekseeva, Maria Sergeeva, Artem V. Fadeev, Kseniya S. Komissarova, Anna A. Ivanova, Tamara S. Simakova, Kirill A. Vasilyev, Anna-Polina Shurygina, Marina A. Stukova, Ksenia R. Safina, Elena R. Nabieva, Sofya K. Garushyants, Galya V. Klink, Evgeny A. Bakin, Jullia V. Zabutova, Anastasia N. Kholodnaia, Olga V. Lukina, Irina A. Skorokhod, Viktoria V. Ryabchikova, Nadezhda V. Medvedeva, Dmitry A. Lioznov, Daria M. Danilenko, Dmitriy M. Chudakov, Andrey B. Komissarov, Georgii A. Bazykin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Here, the authors report accelerated intrahost evolution of SARS-CoV-2 in an immunocompromised patient with non-Hodgkin’s lymphoma with 318 days long COVID-19, and show that changes in the viral genome resulted in escape from T cellular immune resp
Externí odkaz:
https://doaj.org/article/93775c7073a7473ba33c53b0af8cd634
Autor:
Dmitrii S. Shcherbinin, Vadim K. Karnaukhov, Ivan V. Zvyagin, Dmitriy M. Chudakov, Mikhail Shugay
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT-cell receptor (TCR) recognition of foreign peptides presented by the major histocompatibility complex (MHC) initiates the adaptive immune response against pathogens. While a large number of TCR sequences specific to different antigenic
Externí odkaz:
https://doaj.org/article/049b3dfacefa45d383e8fc31bcba2959
Autor:
Mathew Clement, Kristin Ladell, Kelly L Miners, Morgan Marsden, Lucy Chapman, Anna Cardus Figueras, Jake Scott, Robert Andrews, Simon Clare, Valeriia V Kriukova, Ksenia R Lupyr, Olga V Britanova, David R Withers, Simon A Jones, Dmitriy M Chudakov, David A Price, Ian R Humphreys
Publikováno v:
eLife, Vol 12 (2023)
Inhibitory CD4+ T cells have been linked with suboptimal immune responses against cancer and pathogen chronicity. However, the mechanisms that underpin the development of these regulatory cells, especially in the context of ongoing antigen exposure,
Externí odkaz:
https://doaj.org/article/2ebd05a7a8214cc583977dd47ed817fc
Autor:
Vanda Friman, Isabella Quinti, Alexey N. Davydov, Mikhail Shugay, Chiara Farroni, Erik Engström, Shirin Pour Akaber, Sabina Barresi, Ahmed Mohamed, Federica Pulvirenti, Cinzia Milito, Guido Granata, Ezio Giorda, Sara Ahlström, Johanna Karlsson, Emiliano Marasco, Valentina Marcellini, Chiara Bocci, Simona Cascioli, Marco Scarsella, Ganesh Phad, Andreas Tilevik, Marco Tartaglia, Mats Bemark, Dmitriy M. Chudakov, Rita Carsetti, Ola Grimsholm
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112446- (2023)
Summary: Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses. Autoimmune manifestations are common, but B cell central and per
Externí odkaz:
https://doaj.org/article/03982c683b2d450cbf5de2b91419aa00
Autor:
Yulia V. Zhitnyuk, Anastasia P. Koval, Aleksandr A. Alferov, Yanina A. Shtykova, Ilgar Z. Mamedov, Nikolay E. Kushlinskii, Dmitriy M. Chudakov, Dmitry S. Shcherbo
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/6b8c344576fb4eabba78a45b5bcf37e3
Autor:
Anastasia O Smirnova, Anna M Miroshnichenkova, Yulia V Olshanskaya, Michael A Maschan, Yuri B Lebedev, Dmitriy M Chudakov, Ilgar Z Mamedov, Alexander Komkov
Publikováno v:
eLife, Vol 12 (2023)
High-throughput sequencing of adaptive immune receptor repertoires is a valuable tool for receiving insights in adaptive immunity studies. Several powerful TCR/BCR repertoire reconstruction and analysis methods have been developed in the past decade.
Externí odkaz:
https://doaj.org/article/c87c8bb98b6f453b939d96cb7813cfcf