Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Dmitriy Lukashev"'
Autor:
Caroline Gubser Keller, Youngah Shin, Alex Mas Monteys, Nicole Renaud, Martin Beibel, Natalia Teider, Thomas Peters, Thomas Faller, Sophie St-Cyr, Judith Knehr, Guglielmo Roma, Alejandro Reyes, Marc Hild, Dmitriy Lukashev, Diethilde Theil, Natalie Dales, Jang-Ho Cha, Beth Borowsky, Ricardo Dolmetsch, Beverly L. Davidson, Rajeev Sivasankaran
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Huntington’s disease (HD) results from the abnormal expansion of CAG repeats in exon 1 of the HTT gene. Here, the authors show that orally available, brain penetrant molecule branaplam lowers HTT transcript by promoting inclusion of a poison exon o
Externí odkaz:
https://doaj.org/article/917384fbd2e34e4887d645320e87dd19
Autor:
Alessio Paone, Roberta Galli, Chiara Gabellini, Dmitriy Lukashev, Donatella Starace, Agnes Gorlach, Paola De Cesaris, Elio Ziparo, Donatella Del Bufalo, Michail V. Sitkovsky, Antonio Filippini, Anna Riccioli
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 7, Pp 539-549 (2010)
Toll-like receptors (TLRs) recognize microbial/viral-derived components that trigger innate immune response and conflicting data implicate TLR agonists in cancer, either as protumor or antitumor agents. We previously demonstrated that TLR3 activation
Externí odkaz:
https://doaj.org/article/103a58114f2d4477aa747529e2cd11f1
Autor:
Caroline Gubser Keller, Youngah Shin, Alex Mas Monteys, Nicole Renaud, Martin Beibel, Natalia Teider, Thomas Peters, Thomas Faller, Sophie St-Cyr, Judith Knehr, Guglielmo Roma, Alejandro Reyes, Marc Hild, Dmitriy Lukashev, Diethilde Theil, Natalie Dales, Jang-Ho Cha, Beth Borowsky, Ricardo Dolmetsch, Beverly L. Davidson, Rajeev Sivasankaran
Publikováno v:
Nature communications. 13(1)
Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by CAG trinucleotide repeat expansions in exon 1 of the huntingtin (HTT) gene. The mutant HTT (mHTT) protein causes neuronal dysfunction, causing progressive motor, cognit
Autor:
Luis Tecedor, Rajeev Sivasankaran, Beverly L. Davidson, Amy Muehlmatt, Euyn Lim, Alex Mas Monteys, Amiel A Hundley, Paul T. Ranum, Dmitriy Lukashev
Publikováno v:
Nature
So far, gene therapies have relied on complex constructs that cannot be finely controlled(1,2). Here we report a universal switch element that enables precise control of gene replacement or gene editing after exposure to a small molecule. The small-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015640f2b86200db26745d1af22600d3
https://europepmc.org/articles/PMC8966400/
https://europepmc.org/articles/PMC8966400/
Autor:
Alex Mas Monteys, Amiel A. Hundley, Paul T. Ranum, Luis Tecedor, Amy Muehlmatt, Euyn Lim, Dmitriy Lukashev, Rajeev Sivasankaran, Beverly L. Davidson
Publikováno v:
Nature. 602:E25-E25
Autor:
Bryan Belikoff, Michail V. Sitkovsky, Dmitriy Lukashev, Akio Ohta, Robert G. Abbott, Stephen M. Hatfield
Publikováno v:
Cancer Immunology Research. 2:598-605
Hypoxia-driven, A2A adenosine receptor (A2AR)–mediated (hypoxia–A2-adenosinergic), T-cell–autonomous immunosuppression was first recognized as critical and nonredundant in protecting normal tissues from inflammatory damage and autoimmunity. How
Publikováno v:
Expert Opinion on Biological Therapy. 14:419-435
Introduction: Sepsis is an extremely fast-paced disease, initiated by an infection that can progress to multiple organ dysfunction and death. The complexity associated with sepsis makes the therapies difficult to develop. Moreover, the ‘one-fits-al
Autor:
Stephen M. Hatfield, Peter Georgiev, Bryan Belikoff, Michail V. Sitkovsky, Akio Ohta, Dmitriy Lukashev
Publikováno v:
European Journal of Immunology. 43:655-666
Hypoxia-adenosinergic suppression and redirection of the immune response has been implicated in the regulation of antipathogen and antitumor immunity, with hypoxia-inducible factor 1α (HIF-1α) playing a major role. In this study, we investigated th
Publikováno v:
Clinical Cancer Research. 14:5947-5952
Cancerous tissue protection from tumor-recognizing CD8+ and CD4+ T cells (antitumor T cells) limits the therapeutic potential of immunotherapies. We propose that tumor protection is to a large extent due to (a) inhibition of antitumor T cells by hypo
Autor:
Suseela Srinivasan, Courtney M. Lappas, Dmitriy Lukashev, Kevin R. Lynch, Catherine C. Hedrick, David T. Bolick, Michail V. Sitkovsky
Publikováno v:
Diabetes. 57:484-493
OBJECTIVES—Non-obese diabetic (NOD) mice develop spontaneous type 1 diabetes. We have shown that sphingosine-1-phosphate (S1P) reduces activation of NOD diabetic endothelium via the S1P1 receptor. In the current study, we tested the hypothesis that