Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dmitrij Hristodorov"'
Publikováno v:
Antibodies, Vol 3, Iss 1, Pp 92-115 (2014)
Targeted therapies for the treatment of cancer, but also inflammation and autoimmune diseases will reduce major side effects accompanied with conventional treatment modalities. The immunotoxin concept uses bacterial or plant toxins, coupled to antibo
Externí odkaz:
https://doaj.org/article/8141487616654464844d211b75b116a3
Autor:
Theo Thepen, Stefan Barth, Rainer Fischer, Michael Huhn, Radoslav Mladenov, Eric Aslanian, Dmitrij Hristodorov, Sonja Schiffer
Publikováno v:
Antibodies, Vol 2, Iss 1, Pp 9-18 (2013)
Human cytolytic fusion proteins (hCFPs) are comprised of a specific cell-surface-binding moiety and an effector molecule of human origin. In contrast to common immunotoxins, including bacterial or plant toxins, they are considered not to be immunogen
Externí odkaz:
https://doaj.org/article/c4fc28ca06f54d36aa55e814992f431c
Publikováno v:
Toxins, Vol 4, Iss 9, Pp 676-694 (2012)
Diseases caused by chronic inflammation (e.g., arthritis, multiple sclerosis and diabetic ulcers) are multicausal, thus making treatment difficult and inefficient. Due to the age-associated nature of most of these disorders and the demographic transi
Externí odkaz:
https://doaj.org/article/7fa1e3df119f408784b35252be829c6d
Autor:
Olusiji A. Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 36 (2017)
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g., auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mi
Externí odkaz:
https://doaj.org/article/b58b69018c914f209e1a2ad9b38d89fb
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
In normal epithelia, the epithelial cell adhesion molecule (EpCAM) expression is relatively low and only present at the basolateral cell surface. In contrast, EpCAM is aberrantly overexpressed in various human carcinomas. Therefore, EpCAM is consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea71e0953fc9d55f5c4cbe58b11d9e2b
https://doi.org/10.1158/1535-7163.c.6536832.v1
https://doi.org/10.1158/1535-7163.c.6536832.v1
Autor:
Stefan Barth, Theo Thepen, Rainer Fischer, Wijnand Helfrich, Michael Huhn, Anh-Tuan Pham, Stefano Di Fiore, Lea Hein, Nina Berges, Katharina Arens, Judith Niesen, Radoslav Mladenov, Manal Amoury, Dmitrij Hristodorov
Supplementary Figure 1. Cell-binding activity of anti-EpCAM(scFv)-MAP to further target cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce37cdf8635b8b1ddc6d600c2efea6d
https://doi.org/10.1158/1535-7163.22501572.v1
https://doi.org/10.1158/1535-7163.22501572.v1
Publikováno v:
Immunology & Cell Biology. 94:470-478
Classical immunotoxins compromise a binding component (for example, a ligand, antibody or fragment thereof) and a cytotoxic component, usually derived from bacteria or plants (for example, Pseudomonas exotoxin A or ricin). Despite successful testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83369b84990e3100fd9f5054620307cb
https://doi.org/10.1038/icb.2016.4
https://doi.org/10.1038/icb.2016.4
Autor:
Hannes Brehm, Rainer Fischer, Stefan Barth, Dmitrij Hristodorov, Judith Niesen, Alessa Pardo, Radoslav Mladenov, Mehmet Kemal Tur
Publikováno v:
Cancer Letters. 365:149-155
The treatment of rhabdomyosarcoma (RMS) is challenging, and the prognosis remains especially poor for high-grade RMS with metastasis. The conventional treatment of RMS is based on multi-agent chemotherapy combined with resection and radiotherapy, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7266614ba1b4604caaba9cd5bb428f06
https://doi.org/10.1016/j.canlet.2015.04.004
https://doi.org/10.1016/j.canlet.2015.04.004
Autor:
Stefan Barth, Theophilus Thepen, Judith Niesen, Fabian Philipp Kreutzer, Edgar Jost, Lea Hein, Christoph Stein, Hannes Brehm, Tim Stroisch, Dmitrij Hristodorov, Radoslav Mladenov, Rainer Fischer, Tim H. Brümmendorf, Christian Cremer, Bernhard Stockmeyer, Tobias Blume
Publikováno v:
International Journal of Cancer. 137:2729-2738
Antibody-based immunotherapy of leukemia requires the targeting of specific antigens on the surface of blasts. The Fc gamma receptor (CD64) has been investigated in detail, and CD64-targeting immunotherapy has shown promising efficacy in the targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f36a9c929314ac8c7968e471b6e2740
https://doi.org/10.1002/ijc.29628
https://doi.org/10.1002/ijc.29628
Autor:
Shivan Chetty, Neelakshi Mungra, Sandra Jordaan, Olusiji A. Akinrinmade, Dmitrij Hristodorov, Radoslav Mladenov, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 36 (2017)
Biomedicines
Biomedicines
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586f97c028801982f900a97b4da2b01e
https://publica.fraunhofer.de/handle/publica/253674
https://publica.fraunhofer.de/handle/publica/253674