Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dmitrij Golovenko"'
Autor:
Oksana Degtjarik, Dmitrij Golovenko, Yael Diskin-Posner, Lars Abrahmsén, Haim Rozenberg, Zippora Shakked
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The tumor suppressor p53 is mutated in more than half of human cancers and the compound methylene quinuclidinone (MQ) was shown to reactivate p53 mutants by binding covalently to cysteine residues. Here, the authors present crystal structures of wild
Externí odkaz:
https://doaj.org/article/61ab66026ad342f6901e1b078e2ffc95
Autor:
Jessy Safieh, Vasundhara Sharma, Yael Danin-Poleg, Tali E. Haran, Dmitrij Golovenko, Alon Senitzki, Alberto Inga
Publikováno v:
Nucleic Acids Research
Sequence-specific protein-DNA interactions are at the heart of the response of the tumor-suppressor p53 to numerous physiological and stress-related signals. Large variability has been previously reported in p53 binding to and transactivating from p5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14adf47b7843db7dacec5228bcaa771e
http://europepmc.org/articles/PMC7897521
http://europepmc.org/articles/PMC7897521
Autor:
Karina Jouravleva, Dmitrij Golovenko, Gabriel Demo, Robert C. Dutcher, Traci M. Tanaka Hall, Phillip D. Zamore, Andrei A. Korostelev
Publikováno v:
Molecular Cell. 82:4049-4063.e6
SUMMARYIn animals and plants, Dicer enzymes collaborate with double-stranded RNA-binding proteins to convert precursor-microRNAs (pre-miRNAs) into miRNA duplexes. We report six cryo-EM structures of Drosophila Dicer-1 and its partner Loqs-PB. The str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8b2b12fe06d6cacd4e7db621b1a40e
https://doi.org/10.1016/j.molcel.2022.09.002
https://doi.org/10.1016/j.molcel.2022.09.002
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1865:129926
Background Restriction endonucleases belong to prokaryotic restriction-modification systems, that protect host cells from invading DNA. Type II restriction endonucleases recognize short 4–8 bp sequences in the target DNA and cut both DNA strands pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9d98e481f8fe72c41367e4d49e680c
https://doi.org/10.1016/j.bbagen.2021.129926
https://doi.org/10.1016/j.bbagen.2021.129926
Autor:
Zippora Shakked, Itai Beno, Zhiqun Xi, Naama Kessler, Tali E. Haran, Varda Rotter, Dmitrij Golovenko, Pratik Vyas, Yan Stein
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10624-10629
The tumor suppressor protein p53 acts as a transcription factor, binding sequence-specifically to defined DNA sites, thereby activating the expression of genes leading to diverse cellular outcomes. Canonical p53 response elements (REs) are made of tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6e8cc78cffee4a1a3e873fdf75db61
https://doi.org/10.1073/pnas.1618005114
https://doi.org/10.1073/pnas.1618005114
Autor:
Zippora Shakked, Dmitrij Golovenko, Oksana Degtjarik, Lars Abrahmsén, Yael Diskin-Posner, Haim Rozenberg
Publikováno v:
'Nature Communications ', vol: 12, pages: 7057-1-7057-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by regulating the expression of genes critical for cancer prevention. Mutations in the gene encoding p53 are associated with cancer development. PRIMA-1 and epre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa2f84eb5ba41fb3a40825e58a5fcf8
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59048
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59048
Autor:
Dmitrij Golovenko, Haim Rozenberg, Zippora Shakked, Tali E. Haran, Bastian Bräuning, Pratik Vyas
Publikováno v:
Structure (London, England : 1993). 26(9)
The tumor suppressor p53 acts as a transcription factor recognizing diverse DNA response elements (REs). Previous structural studies of p53-DNA complexes revealed non-canonical Hoogsteen geometry of A/T base pairs at conserved CATG motifs leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11717aba7e928d999f30d65bb46f40
https://pubmed.ncbi.nlm.nih.gov/30184478
https://pubmed.ncbi.nlm.nih.gov/30184478
Autor:
Saulius Gražulis, Dmitrij Golovenko, Elena Manakova, Giedrius Sasnauskas, Linas Zakrys, Mindaugas Zaremba, Virginijus Siksnys
Publikováno v:
Nucleic Acids Research
Nucleic acids research, Oxford : Oxford University Press, 2014, vol. 42, no 6, p. 4113-4122
Nucleic acids research, Oxford : Oxford University Press, 2014, vol. 42, no 6, p. 4113-4122
The B3 DNA-binding domains (DBDs) of plant transcription factors (TF) and DBDs of EcoRII and BfiI restriction endonucleases (EcoRII-N and BfiI-C) share a common structural fold, classified as the DNA-binding pseudobarrel. The B3 DBDs in the plant TFs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f23b5d4b544d599c0848c83074684b9
http://europepmc.org/articles/PMC3973309
http://europepmc.org/articles/PMC3973309
Autor:
Elena Manakova, Mindaugas Zaremba, Dmitrij Golovenko, Saulius Gražulis, Giedre Tamulaitiene, Virginijus Siksnys
Publikováno v:
Nucleic Acids Research
Nucleic acids research 40, 6741-51 (2012). doi:10.1093/nar/gks300
Nucleic acids research 40, 6741-51 (2012). doi:10.1093/nar/gks300
Restriction endonuclease Bse634I recognizes and cleaves the degenerate DNA sequence 5'-R/CCGGY-3' (R stands for A or G; Y for T or C, '/' indicates a cleavage position). Here, we report the crystal structures of the Bse634I R226A mutant complexed wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33cd94f3ccecd9fd291c86213b1f3b13
https://doi.org/10.1093/nar/gks300
https://doi.org/10.1093/nar/gks300
Autor:
Rasa Sukackaitė, Jolanta Torresan, Dmitrij Golovenko, Lina Baranauskienė, Vilma Michailovienė, Saulius Gražulis, Jurgis Sūdžius, Sigitas Tumkevicius, Jurgita Matulienė, Jelena Jachno, Elena Manakova, Daumantas Matulis
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:7413-7421
A series of 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides were designed and synthesised. Their binding potencies as inhibitors of selected recombinant human carbonic anhydrase (hCA) isozymes I, II, VII, and XIII were measured using isothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39c267be35881b27a1dcdc99f5d827
https://doi.org/10.1016/j.bmc.2010.09.011
https://doi.org/10.1016/j.bmc.2010.09.011