Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Dmitrii A. Aksenov"'
Autor:
Alexander V. Aksenov, Dinara C. Makieva, Rodion A. Arestov, Nikolai A. Arutiunov, Dmitrii A. Aksenov, Nicolai A. Aksenov, Alexander V. Leontiev, Inna V. Aksenova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8750 (2024)
A new variant of Fisher indole synthesis involving Bronsted acid-catalyzed hydrohydrazination of unactivated terminal and internal acetylenes with arylhydrazines is reported. The use of polyphosphoric acid alone either as the reaction medium or in th
Externí odkaz:
https://doaj.org/article/8eb02c68c4e04646b0fc2a2a35613a72
Autor:
Nicolai A. Aksenov, Nikolai A. Arutiunov, Alexander V. Aksenov, Nikita K. Kirilov, Inna V. Aksenova, Dmitrii A. Aksenov, Elena V. Aleksandrova, Michael Rubin, Alexander Kornienko
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13107 (2023)
The β-carboline motif is common in drug discovery and among numerous biologically active natural products. However, its synthetic preparation relies on multistep sequences and heavily depends on the type of substitution required in the core of the d
Externí odkaz:
https://doaj.org/article/65e2e3694ad245a58c69d5efea7d4eda
Autor:
Alexander V. Aksenov, Dmitrii A. Aksenov, Igor A. Kurenkov, Alexander V. Leontiev, Nicolai A. Aksenov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10213 (2023)
The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)al
Externí odkaz:
https://doaj.org/article/dedaff912f2945018029f67181a0471b
Autor:
Nicolai A. Aksenov, Nikolai A. Arutiunov, Igor A. Kurenkov, Vladimir V. Malyuga, Dmitrii A. Aksenov, Daria S. Momotova, Anna M. Zatsepilina, Elizaveta A. Chukanova, Alexander V. Leontiev, Alexander V. Aksenov
Publikováno v:
Molecules, Vol 28, Iss 9, p 3657 (2023)
A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in
Externí odkaz:
https://doaj.org/article/6e64230369434180b0f330b43580a3ac
Autor:
Vladimir T. Abaev, Nicolai A. Aksenov, Dmitrii A. Aksenov, Elena V. Aleksandrova, Alesia S. Akulova, Igor A. Kurenkov, Alexander V. Leontiev, Alexander V. Aksenov
Publikováno v:
Molecules, Vol 28, Iss 7, p 3162 (2023)
The Friedel–Crafts reaction of novel 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones was used for low cost, one-pot preparation of polycyclic indole derivatives structurally similar to Ergot alkaloids.
Externí odkaz:
https://doaj.org/article/469e8e1c34fa41f2963ace7d3ba5f76e
Autor:
Dmitrii A. Aksenov, Alesia S. Akulova, Elena A. Aleksandrova, Nicolai A. Aksenov, Alexander V. Leontiev, Alexander V. Aksenov
Publikováno v:
Molecules, Vol 28, Iss 5, p 2324 (2023)
A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful f
Externí odkaz:
https://doaj.org/article/05631df6850f4c2d8d25c5e5659639d4
Autor:
Dmitrii A. Aksenov, Nikolai A. Arutiunov, Vladimir V. Maliuga, Alexander V. Aksenov, Michael Rubin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2903-2910 (2020)
Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.
Externí odkaz:
https://doaj.org/article/a6c0f2f18ecd423ab672834f22457116
Autor:
Dmitrii A. Aksenov, Alexander V. Aksenov, Lidiya A. Prityko, Nicolai A. Aksenov, Liliya V. Frolova, Michael Rubin
Publikováno v:
Molbank, Vol 2022, Iss 1, p M1307 (2021)
2-Aryl-2-(3-indolyl)acetohydroxamic acids demonstrate promising antitumor activity, but quickly metabolize in vivo via glucuronidation of hydroxamic acid residue. In an attempt to improve their pharmacokinetics, methyl esters were synthesized via a n
Externí odkaz:
https://doaj.org/article/e62b66c4a526404f832ede9d81419362
Autor:
Alexander V. Aksenov, Nikolai A. Arutiunov, Dmitrii A. Aksenov, Artem V. Samovolov, Igor A. Kurenkov, Nicolai A. Aksenov, Elena A. Aleksandrova, Daria S. Momotova, Michael Rubin
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11120 (2022)
Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves un
Externí odkaz:
https://doaj.org/article/5ea2d92a0739464b8a68b71f110ecf0a
Autor:
Nicolai A. Aksenov, Alexander V. Aksenov, Igor A. Kurenkov, Nikita K. Kirillov, Dmitrii A. Aksenov, Nikolai A. Arutiunov, Daria S. Aksenova, Michael Rubin
Publikováno v:
Molecules, Vol 27, Iss 9, p 2808 (2022)
A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cycliz
Externí odkaz:
https://doaj.org/article/89a9880bc3a74cbab9111368e4beea7f